Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo.
Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo.
复制标题
DOI：
10.1016/j.addr.2013.07.007
复制
发表时间：
2013-12
影响因子：
16.1
通讯作者：
Star, Alexander
中科院分区：
文献类型：
--
作者：
Kotchey, Gregg P.;Zhao, Yong;Kagan, Valerian E.;Star, Alexander
由于其独特的电子、光学和机械特性，碳纳米管 (CNT) 已在治疗和成像应用中得到应用。在理想情况下，碳纳米管在运输其治疗诊断有效载荷后将被丢弃。生物降解代表了一种在交货后消除碳纳米管载体的有吸引力的途径，并且可能是催化货物从运输工具中释放的组成部分。因此，最近的研究工作集中在过氧化物酶驱动的碳纳米管生物降解上。在这篇综述中，我们不仅总结了最近在试管、体外和体内生物降解碳纳米管的努力，而且还尝试探索降解的基本参数。受到迄今为止获得的体内结果的鼓舞，我们展望了未来，专门设计用于靶向器官/细胞、递送其货物并通过过氧化物酶驱动机制进行生物降解的碳基纳米容器将代表纳米医学中有吸引力的治疗递送选择。
As a result of their unique electronic, optical, and mechanical properties, carbon nanotubes (CNTs) have been implemented in therapeutic and imaging applications. In an idealized situation, CNTs would be disposed of after they transport their theranostic payloads. Biodegradation represents an attractive pathway for the eliminating of CNT carriers post-delivery and may be integral in catalyzing the release of the cargo from the delivery vehicle. Accordingly, recent research efforts have focused on peroxidase-driven biodegradation of CNTs. In this review, we not only summarize recent efforts to biodegrade CNTs in the test tube, in vitro, and in vivo, but also attempt to explore the fundamental parameters underlying degradation. Encouraged by the in vivo results obtained to date, we envision a future, where carbon-based nano-containers, which are specifically designed to target organs/cells, deliver their cargo, and biodegrade via peroxidase-driven mechanism, will represent an attractive therapeutic delivery option in nanomedicine.
登录
查看更多内容
影响因子：
--
作者：
Feigel, Ian Matthew;Vedala, Harindra;Star, Alexander
通讯作者：
Star, Alexander
大鼠肺中灌输碳纳米管的生物分布和清除。
影响因子：
10
作者：
Elgrabli D;Floriani M;Abella-Gallart S;Meunier L;Gamez C;Delalain P;Rogerieux F;Boczkowski J;Lacroix G
通讯作者：
Lacroix G
影响因子：
17.1
作者：
Chun, Hyunkyung;Hahm, Myung Gwan;Jung, Yung Joon
通讯作者：
Jung, Yung Joon
影响因子：
15
作者：
Cherukuri, P;Bachilo, SM;Weisman, RB
通讯作者：
Weisman, RB
DOI：
10.1016/s1387-2656(03)09003-3
发表时间：
2003-01-01
期刊：
BIOTECHNOLOGY ANNUAL REVIEW, VOL 9
影响因子：
--
作者：
Azevedo, AM;Martins, VC;Fonseca, LP
通讯作者：
Fonseca, LP