Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria.
Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria.
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利用工程共生细菌提高蚊子对恶性疟原虫的抵抗力
DOI：
10.1126/science.aan5478
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发表时间：
2017-09-29
期刊：
影响因子：
56.9
通讯作者：
Jacobs-Lorena, Marcelo
中科院分区：
文献类型：
--
作者：
Wang, Sibao;Dos-Santos, Andre L. A.;Huang, Wei;Liu, Kun Connie;Oshaghi, Mohammad Ali;Wei, Ge;Agre, Peter;Jacobs-Lorena, Marcelo
疟疾给发展中国家造成的巨大负担迫切要求开发新的方法来防治这一致命疾病。虽然工程共生细菌已被证明可以使蚊子对寄生虫产生抗性，但挑战仍然是将这种细菌有效地引入蚊子种群。我们描述了一种从按蚊卵巢分离的沙雷氏菌属细菌菌株（AS1），该菌株稳定地定殖于蚊子中肠、雌性卵巢和雄性附腺，并在整个蚊子种群中迅速传播。沙雷氏菌AS1基因工程的分泌抗疟原虫效应蛋白，重组菌株抑制恶性疟原虫在蚊子的发展。
The huge burden of malaria in developing countries urgently demands the development of novel approaches to fight this deadly disease. Although engineered symbiotic bacteria have been shown to render mosquitoes resistant to the parasite, the challenge remains to effectively introduce such bacteria into mosquito populations. We describe a Serratia bacterium strain (AS1) isolated from Anopheles ovaries that stably colonizes the mosquito midgut, female ovaries, and male accessory glands and spreads rapidly throughout mosquito populations. Serratia AS1 was genetically engineered for secretion of anti-Plasmodium effector proteins, and the recombinant strains inhibit development of Plasmodium falciparum in mosquitoes.
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影响因子：
4.6
作者：
Bando, Hironori;Okado, Kiyoshi;Guelbeogo, Wamdaogo M.;Badolo, Athanase;Aonuma, Hiroka;Nelson, Bryce;Fukumoto, Shinya;Xuan, Xuenan;Sagnon, N'Fale;Kanuka, Hirotaka
通讯作者：
Kanuka, Hirotaka
影响因子：
6.7
作者：
Isaacs AT;Li F;Jasinskiene N;Chen X;Nirmala X;Marinotti O;Vinetz JM;James AA
通讯作者：
James AA
影响因子：
4.2
作者：
Rani A;Sharma A;Rajagopal R;Adak T;Bhatnagar RK
通讯作者：
Bhatnagar RK
DOI：
10.1073/pnas.0610451104
发表时间：
2007-05-22
影响因子：
11.1
作者：
Favia, Guido;Ricci, Irene;Daffonchio, Daniele
通讯作者：
Daffonchio, Daniele
影响因子：
9.6
作者：
McLean KJ;Jacobs-Lorena M
通讯作者：
Jacobs-Lorena M