Association of Visceral Adipose Tissue and Insulin Resistance with Incident Metabolic Syndrome Independent of Obesity Status: The IRAS Family Study.
Association of Visceral Adipose Tissue and Insulin Resistance with Incident Metabolic Syndrome Independent of Obesity Status: The IRAS Family Study.
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DOI：
10.1002/oby.23177
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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While increasing evidence suggests that visceral adipose tissue (VAT) is a major underlying cause of metabolic syndrome (MetS), few studies have measured VAT at multiple time points in diverse populations. We hypothesized that VAT and insulin resistance differ by MetS status within body mass index (BMI) category in the IRAS Family Study, and further that baseline VAT and insulin resistance and increases over time are associated with incident MetS. We used generalized estimating equations for differences in body fat distribution and insulin resistance by MetS status. We used mixed effects logistic regression for the association of baseline and change in adiposity and insulin resistance with incident MetS across 5 years, adjusted for age, sex, race/ethnicity, and family correlation. VAT and insulin sensitivity differed significantly by MetS status and BMI category at baseline. VAT and HOMA-IR at baseline (VAT OR=1.16 (1.12-2.31); HOMA OR=1.85 (1.32-2.58)) and increase over time (VAT OR=1.55 (1.22-1.98); HOMA OR=3.23 (2.20-4.73)) were associated with incident Mets independent of BMI category. Differing levels of VAT may be driving metabolic heterogeneity within BMI categories. Both overall and abdominal obesity (VAT) may play a role in the development of MetS. Increased VAT over time contributed additional risk.
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影响因子：
4.7
作者：
Bi X;Seabolt L;Shibao C;Buchowski M;Kang H;Keil CD;Tyree R;Silver HJ
通讯作者：
Silver HJ
DOI：
10.1038/ijo.2015.75
发表时间：
2015-09
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Hwang YC;Hayashi T;Fujimoto WY;Kahn SE;Leonetti DL;McNeely MJ;Boyko EJ
通讯作者：
Boyko EJ
DOI：
10.1016/j.numecd.2015.12.002
发表时间：
2016-02-01
影响因子：
3.9
作者：
Shah, Ravi V.;Allison, M. A.;Murthy, V. L.
通讯作者：
Murthy, V. L.
影响因子：
2.8
作者：
Cherqaoui, Rabia;Kassim, Thaslim A.;Randall, Otelio S.
通讯作者：
Randall, Otelio S.
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.