A household-based study of contact networks relevant for the spread of infectious diseases in the highlands of Peru.
A household-based study of contact networks relevant for the spread of infectious diseases in the highlands of Peru.
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DOI：
10.1371/journal.pone.0118457
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
RESPIRA PERU project
中科院分区：
文献类型：
--
作者：
Grijalva CG;Goeyvaerts N;Verastegui H;Edwards KM;Gil AI;Lanata CF;Hens N;RESPIRA PERU project
很少有研究量化了发展中国家偏远农村地区的社会混合情况，那里的传染病负担通常最高。了解这些环境中的社会混合模式对于实施疾病预防和控制战略至关重要。我们的特点是接触和社会混合模式在秘鲁高原的农村社区。这项横断面研究嵌套在一个大型的前瞻性的呼吸道感染的家庭为基础的研究在圣马科斯省，卡哈马卡省秘鲁。研究家庭的成员进行了采访，使用结构化的问卷调查的社会接触（谈话或身体互动）在过去24小时内经历。我们从588名研究家庭成员中确定了9015名报告的接触者。受访者的中位年龄为17岁（四分位距[IQR] 4-34岁）。报告的接触次数中位数为12次（IQR 8-20），而身体接触（即皮肤接触）的中位数为8.5次（IQR 5-14）。研究参与者主要与年龄相仿的人以及他们的子女或父母接触。报告的接触人数主要取决于参与者的年龄、家庭规模和职业。学龄儿童比其他年龄组有更多的接触。家庭内的互惠联系人报告下降与家庭规模（范围70%-100%）。90%的家庭联系网络是完整的，而且，家庭成员与非家庭成员的联系显示出显著的重叠（范围33%-86%），表明高度的联系聚集。模拟了一个两层混合传染病模型，比较了基于观测接触网络的户内混合和户内随机混合。模拟流行病的规模或持续时间没有差异。这项研究表明，在秘鲁的高地农村低密度社区的接触模式是高度的选择性。研究结果支持在这种情况下使用家庭内同质混合假设进行流行病建模。
Few studies have quantified social mixing in remote rural areas of developing countries, where the burden of infectious diseases is usually the highest. Understanding social mixing patterns in those settings is crucial to inform the implementation of strategies for disease prevention and control. We characterized contact and social mixing patterns in rural communities of the Peruvian highlands. This cross-sectional study was nested in a large prospective household-based study of respiratory infections conducted in the province of San Marcos, Cajamarca-Peru. Members of study households were interviewed using a structured questionnaire of social contacts (conversation or physical interaction) experienced during the last 24 hours. We identified 9015 reported contacts from 588 study household members. The median age of respondents was 17 years (interquartile range [IQR] 4–34 years). The median number of reported contacts was 12 (IQR 8–20) whereas the median number of physical (i.e. skin-to-skin) contacts was 8.5 (IQR 5–14). Study participants had contacts mostly with people of similar age, and with their offspring or parents. The number of reported contacts was mainly determined by the participants’ age, household size and occupation. School-aged children had more contacts than other age groups. Within-household reciprocity of contacts reporting declined with household size (range 70%-100%). Ninety percent of household contact networks were complete, and furthermore, household members' contacts with non-household members showed significant overlap (range 33%-86%), indicating a high degree of contact clustering. A two-level mixing epidemic model was simulated to compare within-household mixing based on observed contact networks and within-household random mixing. No differences in the size or duration of the simulated epidemics were revealed. This study of rural low-density communities in the highlands of Peru suggests contact patterns are highly assortative. Study findings support the use of within-household homogenous mixing assumptions for epidemic modeling in this setting.
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影响因子：
--
作者：
Smieszek T
通讯作者：
Smieszek T
DOI：
10.1073/pnas.0706849105
发表时间：
2008-03-25
影响因子：
11.1
作者：
Halloran, M. Elizabeth;Ferguson, Neil M.;Cooley, Philip
通讯作者：
Cooley, Philip
影响因子：
3.8
作者：
Melegaro, Alessia;Jit, Mark;Edmunds, W. John
通讯作者：
Edmunds, W. John
影响因子：
3.7
作者：
Budge, Philip J.;Griffin, Marie R.;Grigalva, Carlos G.
通讯作者：
Grigalva, Carlos G.
影响因子：
5
作者：
Wallinga, Jacco;Teunis, Peter;Kretzschmar, Mirjam
通讯作者：
Kretzschmar, Mirjam