Reproductive factors and risk of estrogen receptor positive, triple-negative, and HER2-neu overexpressing breast cancer among women 20-44 years of age.
Reproductive factors and risk of estrogen receptor positive, triple-negative, and HER2-neu overexpressing breast cancer among women 20-44 years of age.
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DOI：
10.1007/s10549-012-2365-1
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发表时间：
2013-01
影响因子：
3.8
通讯作者：
Malone KE
中科院分区：
文献类型：
--
作者：
Li CI;Beaber EF;Tang MT;Porter PL;Daling JR;Malone KE
生育史是最明确的乳腺癌危险因素之一。然而，人们对它们如何影响不同分子亚型乳腺癌的风险，尤其是年轻女性的风险知之甚少。利用针对 20-44 岁女性的基于人群的病例对照研究的数据，我们评估了各种生殖因素与雌激素受体阳性 (ER+)、三阴性和 HER2 过表达乳腺癌风险之间的关系。详细的生殖史是通过结构化访谈员进行的现场问卷调查获得的。使用多级逻辑回归将对照女性 (n = 941) 的生殖史与 ER+ 病例 (n = 781)、三阴性病例 (n = 180) 和 HER2 过表达病例 (n = 60) 的生育史进行比较。初潮年龄、产次和足月妊娠次数与所有三种乳腺癌亚型的风险相似。相比之下，首次活产年龄、初潮年龄与首次生育年龄之间的间隔以及母乳喂养与三阴性乳腺癌风险呈负相关（趋势P值分别为0.002、0.006和0.018），但与ER+或HER2过表达癌症的风险无关。目前，许多研究都一致观察到母乳喂养与三阴性乳腺癌风险之间存在很强的负相关性，目前母乳喂养是这种侵袭性和致命性乳腺癌最公认的保护因素。需要进一步的研究来阐明这种关系背后的生物学机制，并确认我们关于首次生育年龄以及初潮年龄与首次生育年龄之间的间隔的结果。
Aspects of reproductive history are among the most well-established breast cancer risk factors. However, relatively little is known about how they influence risk of different molecular subtypes of breast cancer, particularly among younger women. Using data from a population-based case–control study of women 20–44 years of age, we assessed the relationships between various reproductive factors and risk of estrogen receptor positive (ER+), triple-negative, and HER2-overexpressing breast cancers. Detailed reproductive histories were obtained through structured interviewer administered in-person questionnaires. Reproductive histories among control women (n = 941) were compared to those of ER+ cases (n = 781), triple-negative cases (n = 180), and HER2-overexpressing cases (n = 60) using polytomous logistic regression. Age at menarche, parity, and number of full-term pregnancies were similarly associated with risk of all three breast cancer subtypes. In contrast, age at first live birth, the interval between age at menarche and age at first birth, and breastfeeding were inversely associated with risk of triple-negative breast cancer (P values for trend 0.002, 0.006 and 0.018, respectively), but were not associated with risk of ER+ or HER2-overexpressing cancers. A strong inverse association between breastfeeding and risk of triple-negative breast cancer has now been consistently observed across numerous studies, and at present it is the most well-established protective factor for this aggressive and lethal form of breast cancer. Further studies clarifying the biological mechanisms underlying this relationship and confirming our results with respect to age at first birth and the interval between age at menarche and age at first birth are needed.
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影响因子：
8.8
作者：
Clavel-Chapelon, F
通讯作者：
Clavel-Chapelon, F
影响因子：
3.8
作者：
Gaudet MM;Press MF;Haile RW;Lynch CF;Glaser SL;Schildkraut J;Gammon MD;Douglas Thompson W;Bernstein JL
通讯作者：
Bernstein JL
影响因子：
8.8
作者：
Andrieu, N;Smith, T;Day, NE
通讯作者：
Day, NE
影响因子：
2.3
作者：
Clavel-Chapelon, F
通讯作者：
Clavel-Chapelon, F
影响因子：
11.2
作者：
Li, Christopher I.;Beaber, Elisabeth F.;Malone, Kathleen E.
通讯作者：
Malone, Kathleen E.