The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells.
The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells.
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DOI：
10.1002/stem.1730
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发表时间：
2014-08
期刊：
影响因子：
5.2
通讯作者：
Bao, Shideng
中科院分区：
文献类型：
--
作者：
Fang, Xiaoguang;Huang, Zhi;Zhou, Wenchao;Wu, Qiulian;Sloan, Andrew E.;Ouyang, Gaoliang;McLendon, Roger E.;Yu, Jennifer S.;Rich, Jeremy N.;Bao, Shideng
关键词：
Glioblastomas are highly lethal brain tumors containing tumor-propagating glioma stem cells (GSCs). The molecular mechanisms underlying the maintenance of the GSC phenotype are not fully defined. Here we demonstrate that the zinc finger and X-linked transcription factor (ZFX) maintains GSC self-renewal and tumorigenic potential by up-regulating c-Myc expression. ZFX is differentially expressed in GSCs relative to non-stem glioma cells and neural progenitor cells (NPCs). Disrupting ZFX by shRNA reduced c-Myc expression and potently inhibited GSC self-renewal and tumor growth. Ectopic expression of c-Myc to its endogenous level rescued the effects caused by ZFX disruption, supporting that ZFX controls GSC properties through c-Myc. Furthermore, ZFX binds to a specific sequence (GGGCCCCG) on the human c-Myc promoter to up-regulate c-Myc expression. These data demonstrate that ZFX functions as a critical upstream regulator of c-Myc and plays essential roles in the maintenance of the GSC phenotype. This study also supports that c-Myc is a dominant driver linking self-renewal to malignancy.
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影响因子：
11.2
作者：
Bonavia R;Inda MM;Cavenee WK;Furnari FB
通讯作者：
Furnari FB
影响因子：
64.5
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Kim J;Woo AJ;Chu J;Snow JW;Fujiwara Y;Kim CG;Cantor AB;Orkin SH
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11.2
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Vescovi, A
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64.5
作者：
Kim, Jonghwan;Chu, Jianlin;Orkin, Stuart H.
通讯作者：
Orkin, Stuart H.