Retroviral mutagenesis of cellular oncogenes: a review with insights into the mechanisms of insertional activation.

Retroviral mutagenesis of cellular oncogenes: a review with insights into the mechanisms of insertional activation.
复制标题

细胞癌基因的逆转录病毒诱变:深入了解插入激活机制的综述。

DOI:
10.1007/978-3-642-76524-7_1
复制
发表时间:
1991
影响因子:
--
通讯作者:
Carter,TH
Carter,TH
中科院分区:
医学3区
文献类型:
--
作者:
Kung,HJ;Boerkoel,C;Carter,TH

文献摘要

参考文献

被引文献

相似文献

逆转录病毒可被视为人类和动物的天然存在的、自我繁殖的诱变剂。它们通过整合到宿主基因组中发挥诱变作用,这是病毒复制周期中的自然步骤。最近体外整合系统的成功开发为这一过程提供了重要的见解(BROWN等1987; Bowerman等1989; Fujiwara和Craigie 1989; Fujiwara和Mizuuchi 1988)以及IN作为参与整合的病毒产物的鉴定(Schwartzberget al. 1984; Donehowerand Varmus 1984; QuintillGrandgenett 1988; Terryet al. 1988; Rothet al. 1988)。关于逆转录病毒整合的优秀评论是可用的(e。例如,在一个实施例中,Grandgenettand Mumm 1990; Varmusand Brown 1989),所以这里只做一个简要的总结。
Retroviruses may be viewed as naturally occurring, self-propagating mutagens of humans and animals. They exert mutagenic effects by integration into the host genome, a natural step in the viral replication cycle. Significant insight into this process has been provided recently by the successful development of in vitro integration systems (BROWN et al. 1987; Bowermanet al. 1989; Fujiwaraand Craigie1989; Fujiwaraand Mizuuchi1988) and the identification of IN as the viral product involved in integration (Schwartzberget al. 1984; Donehowerand Varmus1984; Quinnand Grandgenett1988; Terryet al. 1988; Rothet al. 1988). Excellent reviews on retroviral integration are available (e. g., Grandgenettand Mumm1990; Varmusand Brown1989), so only a brief summary is presented here.
逆转录病毒诱导的 DBA 小鼠淡毛色突变的体细胞和种系回复突变率。
DOI: 10.1073/pnas.85.1.189
发表时间: 1988
影响因子: 11.1
作者:
Seperack,PK;Strobel,MC;Corrow,DJ;Jenkins,NA;Copeland,NG
通讯作者: Copeland,NG
DOI: 10.1093/nar/14.23.9381
发表时间: 1986-12-09
影响因子: 14.9
作者:
EMERMAN, M;TEMIN, HM
通讯作者: TEMIN, HM
DOI: 10.1016/0092-8674(83)90418-x
发表时间: 1983-01-01
期刊: CELL
影响因子: 64.5
作者:
PETERS, G;BROOKES, S;DICKSON, C
通讯作者: DICKSON, C
C-myc 在一种罕见的逆转录病毒诱导的类似于马立克氏​​病的禽 T 淋巴瘤中激活:前病毒插入外显子 1 的 5 增强了内含子启动子的表达。
DOI: --
发表时间: 1987
期刊: Oncogene research
影响因子: --
作者:
R. Isfort;R. Witter;H. Kung
通讯作者: H. Kung
DOI: 10.1016/0092-8674(88)90071-2
发表时间: 1988-08-12
期刊: CELL
影响因子: 64.5
作者:
FUJIWARA, T;MIZUUCHI, K
通讯作者: MIZUUCHI, K