Characterizing the Core Internal Gene Pool of H9N2 Responsible for Continuous Reassortment With Other Influenza A Viruses.
Characterizing the Core Internal Gene Pool of H9N2 Responsible for Continuous Reassortment With Other Influenza A Viruses.
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表征与其他甲型流感病毒持续重配的 H9N2 核心内部基因库
DOI：
10.3389/fmicb.2021.751142
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发表时间：
2021
影响因子：
5.2
通讯作者：
Ren H
中科院分区：
文献类型：
--
作者：
Yang H;Hu M;Wang B;Jin Y;Gong X;Liang L;Yue J;Chen W;Ren H
禽流感病毒间的重配是新亚型禽流感病毒的主要来源。研究表明，H9N2病毒经常捐赠内部片段以产生新的重组禽流感病毒，作为重配模板。然而，重组的内部模式的特点仍然不清楚。在这篇文章中，我们首先定义了H9N2病毒内部片段的核心基因库，这些片段为重配提供了模板。我们使用遗传距离和序列相似性来定义核心基因库中的典型聚类。分析了核心基因库相关菌株的系统发育关系、特征向量距离、地理分布和突变位点。同一典型聚类中的菌株具有较近的系统发育关系和特征向量距离。我们还发现，这些典型集群可以分为三个类别，根据其主要的地理分布区域。此外，在同一地理区域的典型集群包含一些共同的突变模式。我们的研究结果表明，核心基因库中的典型簇在许多方面影响H9N2病毒的重配事件，如地理分布和氨基酸突变位点。
Reassortment among avian influenza viruses is the main source of novel avian influenza virus subtypes. Studies have shown that the H9N2 virus often donates internal segments to generate novel reassortant avian influenza viruses, acting as a reassortment template. However, the characteristics of the internal pattern of reassortment remain unclear. In this article, we first defined the core gene pool of the internal segments of the H9N2 virus that provide templates for reassortment. We used genetic distance and sequence similarity to define typical clusters in the core gene pool. Then, we analyzed the phylogenetic relationships, feature vector distances, geographic distributions and mutation sites of strains related to the core gene pool. Strains in the same typical clusters have close phylogenetic relationships and feature vector distances. We also found that these typical clusters can be divided into three categories according to their main geographic distribution area. Furthermore, typical clusters in the same geographic area contain some common mutation patterns. Our results suggest that typical clusters in the core gene pool affect the reassortment events of the H9N2 virus in many respects, such as geographic distribution and amino acid mutation sites.
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