Obesity and headache: Part II--potential mechanism and treatment considerations.
Obesity and headache: Part II--potential mechanism and treatment considerations.
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DOI：
10.1111/head.12297
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发表时间：
2014-03
期刊：
影响因子：
5
通讯作者：
Peterlin BL
中科院分区：
文献类型：
--
作者：
Chai NC;Bond DS;Moghekar A;Scher AI;Peterlin BL
肥胖和头痛都对个人和社会产生重大影响，流行病学研究一致认为肥胖和头痛之间存在正相关，特别是肥胖和偏头痛之间也存在正相关（见第一部分）。在当前的手稿中，我们将讨论偏头痛与肥胖关联的潜在机制，重点关注偏头痛和调节进食动力之间重叠的中枢和外周病理生理学途径。然后，我们讨论超重和肥胖偏头痛患者以及特发性颅内高压患者的手术、行为和药物治疗注意事项。最后，我们根据这些数据简要讨论未来研究的方向。
Obesity and headache are both associated with a substantial personal and societal impact, and epidemiologic studies have consistently identified a positive association between obesity and headache in general, as well as obesity and migraine specifically (see part I). In the current manuscript, we will discuss the potential mechanisms for the migraine–obesity association, with a focus on the central and peripheral pathophysiological pathways which overlap between migraine and those modulating the drive to feed. We then discuss surgical, behavioral, and pharmacological treatment considerations for overweight and obese migraineurs as well as for those with idiopathic intracranial hypertension. We close by briefly discussing where future research may be headed in light of this data.
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