Dorsal visual stream is preferentially engaged during externally guided action selection in Parkinson Disease.
Dorsal visual stream is preferentially engaged during externally guided action selection in Parkinson Disease.
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DOI：
10.1016/j.clinph.2021.11.077
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Pouratian N
中科院分区：
文献类型：
--
作者：
Sparks H;Cross KA;Choi JW;Courellis H;Thum J;Koenig E;Pouratian N
在帕金森病(PD)患者中，自我模仿或内部暗示(IC)行为被认为受到疾病过程的影响，例如行动启动中的障碍。相比之下，响应感官提示而做出的外部提示(EC)动作可以恢复帕金森病患者显著程度的运动能力，特别是减轻步态冻结。本研究通过视觉空间线索探讨帕金森病患者运动易化的电生理基础，特别关注背侧视流顶叶后皮质(PPC)和外侧运动前皮质(LPMC)轴的动态变化。在深部脑刺激导线植入手术中，获得了PPC和LPMC上的侵入性皮质记录。13名帕金森病被试完成动作选择任务，动作选择任务由左右操纵杆运动与定向视觉提示构成，在IC条件下由内部产生的方向选择组成。比较EC和IC条件下PPC和LPMC内部和之间的时间分辨神经活动。EC条件下的反应时(RT)明显快于IC条件下的反应时间(配对t检验，p=0.0015)。在β频段(13-35赫兹)内，EC的PPC-LPMC点间相位同步显著高于IC条件。只有在EC条件下，运动开始前较大的Ppc-LPMCβ去偏相位滞后指数(DWPLI)与较快的反应时间相关。在运动前和运动期间，EC状态下的多变量Granger因果关系(GC)比IC状态下的要大。相对于IC动作，我们报告了在EC动作的准备和执行期间，β频段内站点间相位同步和定向PPC到LPMC连接的相对增加。此外，连接强度的增加预示着RT的加快，而PD患者的RT在病理上是缓慢的。EC通过β调制通道对PPC-LPMC皮层网络进行更强的参与，可能有助于纠正帕金森氏症患者出现的病理性动作启动减慢。这些发现揭示了帕金森病患者通过视觉空间线索促进运动的电生理机制。
In patients with Parkinson Disease (PD), self-imitated or internally cued (IC) actions are thought to be compromised by the disease process, as exemplified by impairments in action initiation. In contrast, externally-cued (EC) actions which are made in response to sensory prompts can restore a remarkable degree of movement capability in PD, particularly alleviating freezing-of-gait. This study investigates the electrophysiological underpinnings of movement facilitation in PD through visuospatial cuing, with particular attention to the dynamics within the posterior parietal cortex (PPC) and lateral premotor cortex (LPMC) axis of the dorsal visual stream. Invasive cortical recordings over the PPC and LPMC were obtained during deep brain stimulation lead implantation surgery. Thirteen PD subjects performed an action selection task, which was constituted by left or right joystick movement with directional visual cuing in the EC condition and internally generated direction selection in the IC condition. Time-resolved neural activities within and between the PPC and LPMC were compared between EC and IC conditions. Reaction times (RT) were significantly faster in the EC condition relative to the IC condition (paired t-test, p=0.0015). PPC-LPMC inter-site phase synchrony within the β-band (13–35 Hz) was significantly greater in the EC relative to the IC condition. Greater PPC-LPMC β debiased phase lag index (dwPLI) prior to movement onset was correlated with faster reaction times only in the EC condition. Multivariate granger causality (GC) was greater in the EC condition relative to the IC condition, prior to and during movement. Relative to IC actions, we report relative increase in inter-site phase synchrony and directional PPC to LPMC connectivity in the β-band during preparation and execution of EC actions. Furthermore, increased strength of connectivity is predictive of faster RT, which are pathologically slow in PD patients. Stronger engagement of the PPC-LPMC cortical network by an EC specifically through the channel of β-modulation is implicated in correcting the pathological slowing of action initiation seen in Parkinson’s patients. These findings shed light on the electrophysiological mechanisms that underlie motor facilitation in PD patients through visuospatial cuing.
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DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
影响因子：
5.7
作者：
Bichsel, Oliver;Gassert, Roger;Imbach, Lukas L.
通讯作者：
Imbach, Lukas L.
影响因子：
11
作者：
BLOXHAM, CA;DICK, DJ;MOORE, M
通讯作者：
MOORE, M
影响因子：
3.4
作者：
Ciuparu, Andrei;Muresan, Raul C.
通讯作者：
Muresan, Raul C.
影响因子：
1.9
作者：
Ding, MZ;Bressler, SL;Liang, HL
通讯作者：
Liang, HL