Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm.
Blockade of Catecholamine Reuptake in the Prelimbic Cortex Decreases Top-down Attentional Control in Response to Novel, but Not Familiar Appetitive Distracters, within a Timing Paradigm.
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DOI：
10.3390/neurosci1020010
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Buhusi CV
中科院分区：
文献类型：
--
作者：
Matthews AR;Buhusi M;Buhusi CV
情绪激动的分心者会推迟计时行为。增加大脑皮层内的儿茶酚胺水平可以减少令人厌恶的干扰后的延迟，从而对计时产生有益的影响。我们研究了增加大脑皮层中的儿茶酚胺水平是否也能防止由新奇的干扰因素或熟悉的食欲干扰因素造成的有害的计时延迟。大鼠接受高峰间期训练，并在试验中使用新的(未增强的)分心药、熟悉的食欲(食物强化的)分心药，或在初级皮质内局部注入儿茶酚胺再摄取阻滞剂诺米芬新后不使用分心药。预先输注诺米芬新不会改变计时的准确性和精确度。然而，它以倒U形剂量依赖的方式增加了新的分心物造成的延迟，而对食欲分心的人无效。结合以前的研究结果，这些结果表明，初级自上而下注意控制间隔时间的儿茶酚胺能调制因分心者的效价不同而不同：初级儿茶酚胺在呈现熟悉的厌恶分心时增加注意控制，对熟悉的中性或熟悉的食欲分心没有影响，而当呈现新的分心时降低注意控制。这些发现详细说明了儿茶酚胺能调节注意力对时间的调节和刺激的非时间性之间的复杂相互作用，在开发注意力或情感障碍的治疗方法时应该考虑这些因素。
Emotionally charged distracters delay timing behavior. Increasing catecholamine levels within the prelimbic cortex has beneficial effects on timing by decreasing the delay after aversive distracters. We examined whether increasing catecholamine levels within the prelimbic cortex also protects against the deleterious timing delays caused by novel distracters or by familiar appetitive distracters. Rats were trained in a peak-interval procedure and tested in trials with either a novel (unreinforced) distracter, a familiar appetitive (food-reinforced) distracter, or no distracter after being locally infused within the prelimbic cortex with catecholamine reuptake blocker nomifensine. Prelimbic infusion of nomifensine did not alter timing accuracy and precision. However, it increased the delay caused by novel distracters in an inverted-U dose-dependent manner, while being ineffective for appetitive distracters. Together with previous data, these results suggest that catecholaminergic modulation of prelimbic top-down attentional control of interval timing varies with distracter’s valence: prelimbic catecholamines increase attentional control when presented with familiar aversive distracters, have no effect on familiar neutral or familiar appetitive distracters, and decrease it when presented with novel distracters. These findings detail complex interactions between catecholaminergic modulation of attention to timing and nontemporal properties of stimuli, which should be considered when developing therapeutic methods for attentional or affective disorders.
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影响因子：
1.3
作者：
Buhusi, Catalin V.;Matthews, Alexander R.
通讯作者：
Matthews, Alexander R.
影响因子：
2.7
作者：
Buhusi M;Bartlett MJ;Buhusi CV
通讯作者：
Buhusi CV
影响因子：
3.3
作者：
Buhusi M;Olsen K;Buhusi CV
通讯作者：
Buhusi CV
影响因子：
1.9
作者：
Buhusi, CV;Gray, JA;Schmajuk, NA
通讯作者：
Schmajuk, NA
DOI：
10.1037/0097-7403.31.1.18
发表时间：
2005-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
Buhusi, CV;Perera, D;Meck, WH
通讯作者：
Meck, WH