Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli
Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli
复制标题
不同重叠的顺式编码反义RNA调节大肠杆菌毒素-抗毒素系统
作者：
M. Kawano
毒素-抗毒素（TA）系统根据抗毒素的类型分为三类。在I型TA系统中，抗毒素是一种小的反义RNA，其通过与相应的mRNA结合来抑制小的毒性蛋白的翻译。那些I型TA系统最初被鉴定为质粒稳定化模块，其对宿主细胞产生分离后杀伤（PSK）效应。Ⅰ型TA基因座也存在于大肠杆菌染色体上，但其生物学功能尚不清楚。hok/sok和ldr/rdl家族的遗传组织和调控元件非常相似，并且预测毒素含有跨膜结构域，但在其他方面没有可检测的序列相似性。本文将对E. coliK-12，尤其是hok/sok，ldr/rdl和SOS诱导的symE/symR系统，这些系统受顺式编码的反义RNA的调控。
Toxin-antitoxin (TA) systems are categorized into three classes based on the type of antitoxin. In type I TA systems, the antitoxin is a small antisense RNA that inhibits translation of small toxic proteins by binding to the corresponding mRNAs. Those type I TA systems were originally identified as plasmid stabilization modules rendering a post-segregational killing (PSK) effect on the host cells. The type I TA loci also exist on the Escherichia coli chromosome but their biological functions are less clear. Genetic organization and regulatory elements of hok/sok and ldr/rdl families are very similar and the toxins are predicted to contain a transmembrane domain, but otherwise share no detectable sequence similarity. This review will give an overview of the type I TA modules of E. coli K-12, especially hok/sok, ldr/rdl and SOS-inducible symE/symR systems, which are regulated by divergently overlapping cis-encoded antisense RNAs.
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影响因子：
7.2
作者：
Gottesman, Susan;Storz, Gisela
通讯作者：
Storz, Gisela
DOI：
10.1073/pnas.83.1.120
发表时间：
1986-01-01
影响因子：
11.1
作者：
DONOVAN, WP;KUSHNER, SR
通讯作者：
KUSHNER, SR
影响因子：
2.1
作者：
Lemos, JAC;Brown, TA;Burne, RA
通讯作者：
Burne, RA
T4 型噬菌体和细菌中的一个抗 sigma70 蛋白家族，与 AsiA 类似，AsiA 是噬菌体 T4 的转录抑制剂和共激活剂。
影响因子：
5.6
作者：
Pineda,Melissa;Gregory,BrianD;Szczypinski,Bridget;Baxter,KimberlyR;Hochschild,Ann;Miller,EricS;Hinton,DeborahM
通讯作者：
Hinton,DeborahM