Cognitive function following SARS-CoV-2 infection in a population-representative Canadian sample.
Cognitive function following SARS-CoV-2 infection in a population-representative Canadian sample.
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DOI：
10.1016/j.bbih.2022.100454
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Fong GT
中科院分区：
文献类型：
--
作者：
Hall PA;Meng G;Hudson A;Sakib MN;Hitchman SC;MacKillop J;Bickel WK;Fong GT
SARS-CoV-2感染被认为会对大脑产生不利影响，但对社会相关认知功能和决策的影响程度尚未得到充分研究，特别是在那些不太容易受到年龄相关死亡率影响的人群中。目前的研究试图确定感染状态和COVID-19症状严重程度是否与普通人群中青年和中年人的认知功能障碍有关，方法是使用自我报告的执行控制失误和标准化决策任务。调查样本包括1958名平均年龄为37岁的成年人（SD = 10.4）；60.8%为女性。参与者报告了SARS-CoV-2感染史，并在报告先前感染的人中报告了COVID-19症状的严重程度。主要结果是自我报告的认知功能障碍症状，通过简化形式的巴克利执行功能缺陷量表（BDEFS）评估，并在有效的延迟折扣任务中的表现。有SARS-CoV-2感染史的中青年报告的认知功能障碍症状数量（Madj = 1.89, SE = 0.08, CI: 1.74, 2.04; n = 175）明显高于未感染的中青年（Madj = 1.63, SE = 0.08, CI: 1.47,1.80; n = 1599; β = 0.26, p = 0.001）。在感染者中，COVID-19症状严重程度与报告的认知功能障碍水平之间存在剂量反应关系，中度（β = 0.23, CI: 0.003-0.46）和非常/极严重（β = 0.69, CI: 0.22-1.16） COVID-19症状与显著更严重的认知功能障碍相关。在控制了人口统计学、疫苗接种状况、缓解行为频率和地理区域，并剔除住院期间插管的患者后，这些影响仍然可靠，且程度相似。在延迟折扣任务中，以及仅使用PCR确认的SARS-CoV-2病例时，发现了非常相似且相对较大的影响。在没有药物性昏迷史的中青年中，SARS-CoV-2感染史阳性和COVID-19症状严重程度中等及以上与显著的认知功能障碍症状和延迟折扣放大相关。
SARS-CoV-2 infection is believed to adversely affect the brain, but the degree of impact on socially relevant cognitive functioning and decision-making is not well-studied, particularly among those less vulnerable to age-related mortality. The current study sought to determine whether infection status and COVID-19 symptom severity are associated with cognitive dysfunction among young and middled-aged adults in the general population, using self-reported lapses in executive control and a standardized decision-making task. The survey sample comprised 1958 adults with a mean age of 37 years (SD = 10.4); 60.8% were female. Participants reported SARS-CoV-2 infection history and, among those reporting a prior infection, COVID-19 symptom severity. Primary outcomes were self-reported symptoms of cognitive dysfunction assessed via an abbreviated form of the Barkley Deficits in Executive Functioning Scale (BDEFS) and performance on a validated delay-discounting task. Young and middle-aged adults with a positive SARS-CoV-2 infection history reported a significantly higher number of cognitive dysfunction symptoms (Madj = 1.89, SE = 0.08, CI: 1.74, 2.04; n = 175) than their non-infected counterparts (Madj = 1.63, SE = 0.08, CI: 1.47,1.80; n = 1599; β = 0.26, p = .001). Among those infected, there was a dose-response relationship between COVID-19 symptom severity and level of cognitive dysfunction reported, with moderate (β = 0.23, CI: 0.003–0.46) and very/extremely severe (β = 0.69, CI: 0.22–1.16) COVID-19 symptoms being associated with significantly greater cognitive dysfunction. These effects remained reliable and of similar magnitude after controlling for demographics, vaccination status, mitigation behavior frequency, and geographic region, and after removal of those who had been intubated during hospitalization. Very similar—and comparatively larger—effects were found for the delay-discounting task, and when using only PCR confirmed SARS-CoV-2 cases. Positive SARS-CoV-2 infection history and moderate or higher COVID-19 symptom severity are associated with significant symptoms of cognitive dysfunction and amplified delay discounting among young and middle-aged adults with no history of medically induced coma.
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影响因子：
15.1
作者：
Hampshire A;Trender W;Chamberlain SR;Jolly AE;Grant JE;Patrick F;Mazibuko N;Williams SC;Barnby JM;Hellyer P;Mehta MA
通讯作者：
Mehta MA
影响因子：
2.3
作者：
Koffarnus, Mikhail N.;Bickel, Warren K.
通讯作者：
Bickel, Warren K.
COVID-19 住院康复患者客观认知缺陷的频率和概况。
DOI：
10.1038/s41386-021-00978-8
发表时间：
2021-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Jaywant A;Vanderlind WM;Alexopoulos GS;Fridman CB;Perlis RH;Gunning FM
通讯作者：
Gunning FM
影响因子：
6
作者：
Bickel, WK;Marsch, LA
通讯作者：
Marsch, LA
影响因子：
2.8
作者：
Ladds E;Rushforth A;Wieringa S;Taylor S;Rayner C;Husain L;Greenhalgh T
通讯作者：
Greenhalgh T