Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder - A multiplex multigenerational neuroimaging study.
Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder - A multiplex multigenerational neuroimaging study.
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DOI：
10.1016/j.ebiom.2018.08.048
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发表时间：
2018-10
期刊：
影响因子：
11.1
通讯作者：
van der Wee NJA
中科院分区：
文献类型：
--
作者：
Bas-Hoogendam JM;van Steenbergen H;Tissier RLM;Houwing-Duistermaat JJ;Westenberg PM;van der Wee NJA
社交焦虑症（SAD）是一种具有遗传背景的致残性精神疾病。先前已报道过与 SAD 相关的大脑灰质 (GM) 改变，但 GM 指标是否是 SAD 的候选内表型仍有待阐明。内表型是从基因型到表型的因果途径上可测量的特征，为基于遗传的疾病机制提供了见解。基于对现有证据的审查，我们使用来自 SAD 患者及其两代家庭成员的独特样本的数据，检查了 GM 特征是否满足两个内表型标准。首先，我们研究了在 SAD 基因富集的家庭中，GM 特征是否与社交焦虑共分离。其次，估计了转基因特征的遗传力。有 SAD 遗传倾向的家庭参加了莱顿家庭实验室的 SAD 研究；获得 T1 加权 MRI 脑部扫描（n = 110，8 个家庭）。确定先验确定的感兴趣区域（ROI）的皮层下体积、皮层厚度和皮层表面积。接下来，估计了社交焦虑和遗传力的关联。来自额叶、顶叶和颞叶 ROI 的几种皮质下和皮质 GM 特征与家庭内的社交焦虑（未校正的 p 水平）共同分离，并表现出中度至高度的遗传力。这些发现提供了初步证据，证明分布在大脑中的多个 ROI 的 GM 特征是 SAD 的候选内表型。因此，他们揭示了 SAD 的遗传脆弱性。未来的研究需要证实这些结果，并将它们与大脑功能改变以及这些转基因变化背后的遗传变异联系起来。莱顿大学研究简介“健康、预防和人类生命周期”。研究人员检查了灰质（GM）特征，探索其作为社交焦虑症（SAD）内表型的潜力。在 SAD 基因丰富的家庭中，一些 GM 特征与社交焦虑是共分离的，并且是可遗传的。这些发现表明 GM 特征是 SAD 的候选内表型。
Social anxiety disorder (SAD) is a disabling psychiatric condition with a genetic background. Brain alterations in gray matter (GM) related to SAD have been previously reported, but it remains to be elucidated whether GM measures are candidate endophenotypes of SAD. Endophenotypes are measurable characteristics on the causal pathway from genotype to phenotype, providing insight in genetically-based disease mechanisms. Based on a review of existing evidence, we examined whether GM characteristics meet two endophenotype criteria, using data from a unique sample of SAD-patients and their family-members of two generations. First, we investigated whether GM characteristics co-segregate with social anxiety within families genetically enriched for SAD. Secondly, heritability of the GM characteristics was estimated. Families with a genetic predisposition for SAD participated in the Leiden Family Lab study on SAD; T1-weighted MRI brain scans were acquired (n = 110, 8 families). Subcortical volumes, cortical thickness and cortical surface area were determined for a-priori determined regions of interest (ROIs). Next, associations with social anxiety and heritabilities were estimated. Several subcortical and cortical GM characteristics, derived from frontal, parietal and temporal ROIs, co-segregated with social anxiety within families (uncorrected p-level) and showed moderate to high heritability. These findings provide preliminary evidence that GM characteristics of multiple ROIs, which are distributed over the brain, are candidate endophenotypes of SAD. Thereby, they shed light on the genetic vulnerability for SAD. Future research is needed to confirm these results and to link them to functional brain alterations and to genetic variations underlying these GM changes. Leiden University Research Profile ‘Health, Prevention and the Human Life Cycle’. Gray matter (GM) characteristics were examined exploring their potential as endophenotypes of social anxiety disorder (SAD). Several GM characteristics co-segregated with social anxiety within families genetically enriched for SAD and were heritable. These findings suggest that GM characteristics are candidate endophenotypes of SAD.
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影响因子：
4.2
作者：
Bas-Hoogendam, Janna Marie;van Steenbergen, Henk;van der Wee, Nic J. A.
通讯作者：
van der Wee, Nic J. A.
影响因子：
3.1
作者：
Bandelow, Borwin;Baldwin, David;Riederer, Peter
通讯作者：
Riederer, Peter
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
4.8
作者：
Arsalidou, Marie;Duerden, Emma G.;Taylor, Margot J.
通讯作者：
Taylor, Margot J.
影响因子：
4.4
作者：
Acarturk, C.;de Graaf, Ron;Cuijpers, P.
通讯作者：
Cuijpers, P.