In vivo Morphometry of Inner Plexiform Layer (IPL) Stratification in the Human Retina With Visible Light Optical Coherence Tomography.

In vivo Morphometry of Inner Plexiform Layer (IPL) Stratification in the Human Retina With Visible Light Optical Coherence Tomography.
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DOI:
10.3389/fncel.2021.655096
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发表时间:
2021
影响因子:
5.3
通讯作者:
Srinivasan VJ
Srinivasan VJ
中科院分区:
医学2区
文献类型:
--
作者:
Zhang T;Kho AM;Srinivasan VJ

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从双极细胞到更高的大脑视觉中心,脊椎动物视觉系统中的信号沿着平行的开和关路径传递。这两条通路沿着视网膜的深度轴在空间上分开。然而,据我们所知,没有办法在体内直接评估这种解剖分层。在这里,利用超高分辨率可见光相干断层扫描(OCT)在人体中成像,我们报告了与IPL分层平行的内丛状层(IPL)的刻板反射率模式。我们在一组正常的年轻成人受试者中对这种非侵入性反射模式的地形进行了表征。这种提出的IPL分层的相关性可以通过对活人的非侵入性眼部成像来获得。在设计视觉系统发育或疾病的研究时,应仔细考虑地形变化。
From the bipolar cells to higher brain visual centers, signals in the vertebrate visual system are transmitted along parallel on and off pathways. These two pathways are spatially segregated along the depth axis of the retina. Yet, to our knowledge, there is no way to directly assess this anatomical stratification in vivo. Here, employing ultrahigh resolution visible light Optical Coherence Tomography (OCT) imaging in humans, we report a stereotyped reflectivity pattern of the inner plexiform layer (IPL) that parallels IPL stratification. We characterize the topography of this reflectivity pattern non-invasively in a cohort of normal, young adult human subjects. This proposed correlate of IPL stratification is accessible through non-invasive ocular imaging in living humans. Topographic variations should be carefully considered when designing studies in development or diseases of the visual system.
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