Cellular-Scale Imaging of Transparent Retinal Structures and Processes Using Adaptive Optics Optical Coherence Tomography.
Cellular-Scale Imaging of Transparent Retinal Structures and Processes Using Adaptive Optics Optical Coherence Tomography.
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DOI：
10.1146/annurev-vision-030320-041255
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发表时间：
2020-09-15
影响因子：
6
通讯作者：
Kurokawa K
中科院分区：
文献类型：
--
作者：
Miller DT;Kurokawa K
高分辨率视网膜成像正在彻底改变科学家和临床医生在细胞尺度上研究视网膜的方式。它的灵敏度使延时光学活检能够捕捉活体眼睛中细胞结构和生理过程的微小变化。这些信息越来越多地用于检测疾病发作和监测早期疾病进展，提高了个性化眼科护理的可能性。强大的高分辨率成像工具已经开发了二十多年;近年来引起了相当大的兴趣的是自适应光学增强的光学相干断层扫描。最先进的自适应光学相干断层扫描（AO-OCT）使其能够可视化甚至高度透明的细胞，并在视网膜内的所有深度测量它们的一些内部过程，从而可以重建活体显微视网膜的3D视图。在这篇综述中，我们报告了目前的AO-OCT性能及其在可视化和量化这些曾经不可见的细胞在人眼中的成功。
High-resolution retinal imaging is revolutionizing how scientists and clinicians study the retina on the cellular scale. Its exquisite sensitivity enables time-lapse optical biopsies that capture minute changes in the structure and physiological processes of cells in the living eye. This information is increasingly used to detect disease onset and monitor disease progression during early stages, raising the possibility of personalized eye care. Powerful high-resolution imaging tools have been in development for more than two decades; one that has garnered considerable interest in recent years is optical coherence tomography enhanced with adaptive optics. State-of-the-art adaptive optics optical coherence tomography (AO-OCT) makes it possible to visualize even highly transparent cells and measure some of their internal processes at all depths within the retina, permitting reconstruction of a 3D view of the living microscopic retina. In this review, we report current AO-OCT performance and its success in visualizing and quantifying these once-invisible cells in human eyes.
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影响因子：
11.2
作者：
CURCIO, CA;DRUCKER, DN
通讯作者：
DRUCKER, DN
三维光学相干断层扫描视网膜层光强度的定量分析。
影响因子：
4.4
作者：
Chen, Xinjian;Hou, Ping;Chen, Haoyu
通讯作者：
Chen, Haoyu
影响因子：
3.8
作者：
Cense, Barry;Koperda, Eric;Miller, Donald T.
通讯作者：
Miller, Donald T.
影响因子：
10.4
作者：
Azimipour, Mehdi;Migacz, Justin, V;Jonnal, Ravi S.
通讯作者：
Jonnal, Ravi S.
影响因子：
4.2
作者：
Blanks, JC;Torigoe, Y;Blanks, RHI
通讯作者：
Blanks, RHI