Exaggerated activation of dorsal anterior cingulate cortex during cognitive interference: a monozygotic twin study of posttraumatic stress disorder.
Exaggerated activation of dorsal anterior cingulate cortex during cognitive interference: a monozygotic twin study of posttraumatic stress disorder.
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在认知干扰期间，背扣带回皮层的夸大激活：创伤后应激障碍的单卵双胞胎研究。
DOI：
10.1176/appi.ajp.2011.09121812
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Pitman RK
中科院分区：
文献类型：
--
作者：
Shin LM;Bush G;Milad MR;Lasko NB;Brohawn KH;Hughes KC;Macklin ML;Gold AL;Karpf RD;Orr SP;Rauch SL;Pitman RK
神经影像学研究揭示了创伤后应激障碍（PTSD）患者的前扣带皮层功能异常。当前研究的目的是确定PTSD的背前扣带高反应性是一种获得性特征还是家族性危险因素。采用病例对照双胞胎设计，我们研究了患有创伤后应激障碍的战斗暴露退伍军人（n=12）和他们的同卵双胞胎（n=12），以及没有创伤后应激障碍的战斗暴露退伍军人（n=14）和他们的同卵双胞胎（n=14）。参与者在完成多源干扰任务期间接受了功能性磁共振成像，这可以可靠地激活背前扣带。与非创伤后应激障碍退伍军人及其双胞胎相比，患有创伤后应激障碍的退伍军人及其双胞胎在前扣带背侧有更大的激活，并且往往有更大的反应时差得分。暴露双胞胎的背前扣带激活与PTSD症状严重程度呈正相关。未暴露的双胞胎的背前扣带激活与他们的战斗暴露的双胞胎的创伤后应激障碍症状严重程度呈正相关，但与战斗暴露的双胞胎的抑郁或酒精使用严重程度无关。前扣带背侧的高反应性似乎是心理创伤后PTSD发展的家族性危险因素。
Neuroimaging studies have revealed functional abnormalities in the anterior cingulate cortex in posttraumatic stress disorder (PTSD). The goal of the current research was to determine whether hyperresponsivity of the dorsal anterior cingulate in PTSD is an acquired characteristic or familial risk factor. Using a case-control twin design, we studied combat-exposed veterans with PTSD (n=12) and their identical combat-unexposed co-twins (n=12), as well as combat-exposed veterans without PTSD (n=14) and their identical combat-unexposed co-twins (n=14). Participants underwent functional magnetic resonance imaging during completion of the Multi-Source Interference Task, which reliably activates the dorsal anterior cingulate. Combat veterans with PTSD and their co-twins had significantly greater activation in the dorsal anterior cingulate and tended to have larger response time difference scores, as compared to non-PTSD veterans and their co-twins. Dorsal anterior cingulate activation in the exposed twins was positively correlated with their PTSD symptom severity. Dorsal anterior cingulate activation in the unexposed twins was positively correlated with their combat-exposed co-twins’ PTSD symptom severity, but not with depression or alcohol use severity in the combat-exposed co-twins. Hyperresponsivity in the dorsal anterior cingulate appears to be a familial risk factor for the development of PTSD following psychological trauma.
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影响因子：
2.3
作者：
Hayes, Jasmeet Pannu;LaBar, Kevin S.;Petty, Christopher M.;McCarthy, Gregory;Morey, Rajendra A.
通讯作者：
Morey, Rajendra A.
影响因子：
25
作者：
Bishop, S;Duncan, J;Lawrence, AD
通讯作者：
Lawrence, AD
影响因子：
14.5
作者：
Critchley, HD;Mathias, CJ;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
3.7
作者：
Mohanty, Aprajita;Engels, Anna S.;Miller, Gregory A.
通讯作者：
Miller, Gregory A.
影响因子：
6.9
作者：
Bremner, JD;Vermetten, E;Charney, DS
通讯作者：
Charney, DS