Cadmium, lead, and other metals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicant.
Cadmium, lead, and other metals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicant.
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与精液质量有关的镉，铅和其他金属：人类作为男性生殖毒物的人类证据。
DOI：
10.1289/ehp.11490
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发表时间：
2008-11
影响因子：
10.4
通讯作者：
Wirth, Julia J.
中科院分区：
文献类型：
--
作者：
Meeker, John D.;Rossano, Mary G.;Protas, Bridget;Diamond, Michael P.;Puscheck, Elizabeth;Daly, Douglas;Paneth, Nigel;Wirth, Julia J.
关于人类精液质量与暴露于各种金属（包括必需金属（如锌、铜）和非必需金属（如镉、铅））有关的证据是不一致的。迄今为止，大多数研究使用的样本量较小，无法解释重要的协变量。我们在这项研究中的目的是评估在环境水平上暴露于多种金属与人类精液质量参数之间的关系。我们测量了219名男性的精液质量和血液中的金属（砷、镉、铬、铜、铅、锰、汞、钼、硒和锌）。我们使用了多种统计方法来评估金属与精液质量之间的关系，同时考虑了重要的协变量和各种金属。在许多值得注意的发现中，涉及Mo的关联在各种统计方法中是最一致的。我们发现，即使考虑到潜在的混杂因素和其他金属，钼与精子浓度下降和正常形态之间也存在剂量依赖性趋势。例如，在低、中、高钼组中，精子浓度的校正优势比（or）为1.0（参考）、1.4[95%可信区间（CI）， 0.5-3.7]和3.5 (95% CI, 1.1-11)，形态学的校正优势比为1.0（参考）、0.8 （95% CI, 0.3-1.9）和2.6 （95% CI, 1.0 - 7.0）。我们还发现了Mo与低Cu或Zn之间相互作用的初步证据。在分层分析中，高Mo/低Cu组精子浓度和形态低于参考值的调整ORs分别为14.4（1.6,132）和13.7（1.6,114）。我们的发现代表了Mo和精液质量负相关的第一个人类证据。这些关系与动物数据一致，但还需要进一步的人体和机械研究。
Evidence on human semen quality as it relates to exposure to various metals, both essential (e.g., zinc, copper) and nonessential (e.g., cadmium, lead), is inconsistent. Most studies to date used small sample sizes and were unable to account for important covariates. Our goal in this study was to assess relationships between exposure to multiple metals at environmental levels and human semen-quality parameters. We measured semen quality and metals in blood (arsenic, Cd, chromium, Cu, Pb, manganese, mercury, molybdenum, selenium, and Zn) among 219 men recruited through two infertility clinics. We used multiple statistical approaches to assess relationships between metals and semen quality while accounting for important covariates and various metals. Among a number of notable findings, the associations involving Mo were the most consistent over the various statistical approaches. We found dose-dependent trends between Mo and declined sperm concentration and normal morphology, even when considering potential confounders and other metals. For example, adjusted odds ratios (ORs) for below-reference semen-quality parameters in the low, medium, and high Mo groups were 1.0 (reference), 1.4 [95% confidence interval (CI), 0.5–3.7], and 3.5 (95% CI, 1.1–11) for sperm concentration and 1.0 (reference), 0.8 (95% CI, 0.3–1.9), and 2.6 (95% CI, 1.0–7.0) for morphology. We also found preliminary evidence for interactions between Mo and low Cu or Zn. In stratified analyses, the adjusted ORs in the high Mo/low Cu group were 14.4 (1.6, 132) and 13.7 (1.6, 114) for below-reference sperm concentration and morphology, respectively. Our findings represent the first human evidence for an inverse association between Mo and semen quality. These relationships are consistent with animal data, but additional human and mechanistic studies are needed.
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