Response of the mouse sublingual gland to spaceflight.
Response of the mouse sublingual gland to spaceflight.
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DOI：
10.1111/eos.12541
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发表时间：
2018-10
影响因子：
1.9
通讯作者：
Hand AR
中科院分区：
文献类型：
--
作者：
Dagdeviren D;Beallias J;Khan I;Mednieks MI;Hand AR
本文研究了美国发现号航天飞机（STS-131）和亚特兰蒂斯号航天飞机（STS-135）上小鼠舌下腺分泌蛋白的超微结构和免疫组织化学。地面对照组和飞行组小鼠舌下腺粘液腺泡或浆液性半月形细胞结构无差异。相反，以前的研究表明，自噬和凋亡的腮腺浆液性腺泡细胞在飞行小鼠。STS-131飞行小鼠舌下半月板细胞中腮腺分泌蛋白（PSP）的表达显著高于地面对照小鼠，而STS-135飞行小鼠则显著低于地面对照小鼠。同样，腺泡细胞中的粘蛋白（Muc 19）表达和半月形细胞中的PKA-RII表达在STS-131飞行小鼠中增加，在STS-135飞行小鼠中减少，但不显著。两次飞行小鼠的半月形细胞和腮腺蛋白（DCPP）略有减少，核PKA-RII略有增加。这些结果表明，唾液腺对航天条件的反应在不同的腺体、细胞类型和分泌蛋白之间存在差异。此外，航天环境，包括微重力的影响，改变蛋白质的表达。确定唾液蛋白的变化可能会导致非侵入性方法的发展，以评估宇航员的生理状态。
The ultrastructure and immunohistochemistry of secretory proteins of sublingual glands were studied in mice flown on the US space shuttles Discovery (Space Transportation System [STS]-131) and Atlantis (STS-135). No differences in mucous acinar or serous demilune cell structure were observed between sublingual glands of ground control and flight mice. In contrast, previous studies showed autophagy and apoptosis of parotid serous acinar cells in flight mice. The expression of parotid secretory protein (PSP) in sublingual demilune cells of STS-131 flight mice was significantly increased compared to ground control mice but decreased in STS-135 flight mice. Similarly, mucin (Muc19) expression in acinar cells and PKA-RII expression in demilune cells were increased in STS-131 flight mice and decreased in STS-135 flight mice, but not significantly. Demilune cell and parotid protein (DCPP) was slightly decreased in mice from both flights, and nuclear PKA-RII was slightly increased. These results indicate that the response of salivary glands to spaceflight conditions varies among the different glands, cell types and secretory proteins. Additionally, the spaceflight environment, including the effects of microgravity, modifies protein expression. Determining changes in salivary proteins may lead to development of non-invasive methods to assess the physiological status of astronauts.
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影响因子：
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作者：
Malamud D
通讯作者：
Malamud D
影响因子：
3.2
作者：
Das, Biswadip;Cash, Melanie N.;Culp, David J.
通讯作者：
Culp, David J.
DOI：
10.1067/mod.2002.121011
发表时间：
2002-03-01
影响因子：
3
作者：
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通讯作者：
Mednieks, MI
影响因子：
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作者：
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通讯作者：
Richardson, Sara
影响因子：
4
作者：
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通讯作者：
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