Reward and affective regulation in depression-prone smokers.
Reward and affective regulation in depression-prone smokers.
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DOI：
10.1016/j.biopsych.2014.04.018
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发表时间：
2014-11-01
影响因子：
10.6
通讯作者：
Strasser AA
中科院分区：
文献类型：
--
作者：
Audrain-McGovern J;Wileyto EP;Ashare R;Cuevas J;Strasser AA
在容易患抑郁症的人中，吸烟率高得不成比例。虽然抑郁症被概念化为一种积极情绪调节失调和奖赏过程中断的疾病，但很少有研究确定吸烟在有抑郁倾向的吸烟者的这些过程中所起的作用。有抑郁倾向的吸烟者(DP+；n=34)和不容易抑郁的吸烟者(DP-；n=49)接受了两次实验室会议，一次是在戒烟时，一次是在随意吸烟时，以评估吸烟和奖励敏感性的相对强化价值。采用经验抽样的方法，参与者完成了在正常吸烟三天和戒烟三天期间的主观奖励、积极情绪和负面情绪的自我报告测量。与DP-相比，DP+在选择任务中的累进比率(OR2.05；CI 95%1.04至4.06p=0.039)对香烟泡芙起作用的可能性是金钱的两倍。通过信号检测任务测量的奖励敏感度没有产生任何重要的发现。混合模型回归显示主观奖赏、消极情感和积极情感存在三向交互作用(抑郁组、吸烟阶段和时间)。对于所有这三种结果，DP-和DP+的斜率彼此之间有显著差异(p‘s<；0.05)，随着时间的推移，吸烟(与戒烟)对DP+的影响比DP-吸烟者更大(p’s<；0.05)。这些发现表明，吸烟对奖赏和积极情绪调节的影响是DP+吸烟者特有的，并强调了在这一人群中戒烟治疗的新靶点。
There is a disproportionately high smoking prevalence among individuals who are prone to depression. While depression has been conceptualized as a disorder of dysregulated positive affect and disrupted reward processing, little research has been conducted to determine the role of smoking in these processes among depression-prone smokers. Depression-prone smokers (DP+; n = 34) and smokers not depression-prone (DP-; n=49) underwent two laboratory sessions, once while smoking abstinent and once while smoking ad-libitum, to assess the relative reinforcing value of smoking and reward sensitivity. Using experience sampling methods, participants completed self-report measures of subjective reward, positive affect, and negative affect across three days while smoking as usual and three days while smoking abstinent. DP+ were two times more likely to work for cigarette puffs versus money in a progressive ratio, choice task (OR 2.05; CI 95% 1.04 to 4.06, p=0.039) compared to DP-. Reward sensitivity as measured by the signal detection task did not yield any significant findings. Mixed models regressions revealed a 3-way interaction (depression group, smoking phase, and time) for subjective reward, negative affect and positive affect. For all three of these outcomes, the slopes for DP- and DP+ differed significantly from each other (p's < 0.05), and the effect of smoking (vs. abstinence) over time was greater for DP+ than DP- smokers (p's <0.05). These findings indicate that the effects of smoking on reward and positive affect regulation are specific to DP+ smokers and highlight novel targets for smoking cessation treatment in this population.
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影响因子：
4.4
作者：
Audrain-McGovern, Janet;Rodriguez, Daniel;Epstein, Leonard H.;Rodgers, Kelli;Cuevas, Jocelyn;Wileyto, E. Paul
通讯作者：
Wileyto, E. Paul
影响因子：
3.4
作者：
Campbell, UC;Carroll, ME
通讯作者：
Carroll, ME
影响因子：
4.4
作者：
Correia, CJ;Simons, J;Borsari, BE
通讯作者：
Borsari, BE
影响因子：
17.7
作者：
Covey, LS;Glassman, AH;Stage, K
通讯作者：
Stage, K
影响因子：
3.4
作者：
Cook, Jessica Werth;Spring, Bonnie;McChargue, Dennis
通讯作者：
McChargue, Dennis