Psychophysiological biomarkers of workplace stressors.

Psychophysiological biomarkers of workplace stressors.
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DOI:
10.1016/j.neubiorev.2009.11.005
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发表时间:
2010-09
影响因子:
8.2
通讯作者:
Kumari, Meena
Kumari, Meena
中科院分区:
医学1区
文献类型:
--
作者:
Chandola, Tarani;Heraclides, Alexandros;Kumari, Meena

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工作场所的压力源与更大的冠心病风险有关,尽管对工作压力的心理生理后果存在争议。这项研究建立在最近的评论和检查的文献联系工作压力与交感肾上腺生物标志物(血浆儿茶酚胺和心率变异性)和HPA轴生物标志物-皮质醇的早晨后配置文件。使用适当的检索词,使用文献数据库PubMed、Embase、Biosys和Toxline检索相关研究。回顾了4项关于血浆儿茶酚胺的研究,10项关于心率变异性的研究和16项关于晨后皮质醇的研究。在大多数研究HRV和工作压力的相关性的研究中,更多的工作压力报告与较低的心率变异性相关。血浆儿茶酚胺和皮质醇分泌的研究结果不太明确,而且总体上研究质量较差。有证据表明,工作压力与交感肾上腺和HPA轴生物标志物的应激反应升高有关。
Workplace stressors are associated with greater coronary heart disease risk, although there is debate over the psychophysiological consequences of work stress. This study builds on recent reviews and examines the literature linking work stress with sympatho-adrenal biomarkers (plasma catecholamines and heart rate variability) and HPA axis biomarkers- the post-morning profile of cortisol. Relevant studies using appropriate search terms were searched using the bibliographic databases PubMed, Embase, Biosys and Toxline. Four studies on plasma catecholamines, ten studies on heart rate variability, and sixteen studies on post-morning cortisol were reviewed. In the majority of studies that examined the association of HRV and work stress, greater reports of work stress is associated with lower heart rate variability. The findings for plasma catecholamines and cortisol secretion are less clear cut and suffer from poorer quality of studies in general. There is evidence that work stress is related to elevated stress responses in terms of sympatho-adrenal and HPA axis biomarkers.
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