Glucose administration before exercise modulates catecholaminergic responses in glycogen-depleted subjects.
Glucose administration before exercise modulates catecholaminergic responses in glycogen-depleted subjects.
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运动前给予葡萄糖可调节糖原耗尽受试者的儿茶酚胺能反应。
DOI：
10.1152/jappl.1997.82.1.248
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Sagnol,M
中科院分区：
文献类型：
--
作者：
Gozal,D;Thiriet,P;Cottet-Emard,JM;Wouassi,D;Bitanga,E;Geyssant,A;Pequignot,JM;Sagnol,M
Gozal、David、Patrice Thiriet、Jean Marie Cottet-Emard、Dieudonné Wouassi、Emmanuel Bitanga、André Geyssant、Jean Marc Pequignot 和 Marcel Sagnol。运动前给予葡萄糖可调节糖原耗尽受试者的儿茶酚胺能反应。应用。 Physiol.82(1): 248–256, 1997.—在糖原耗尽的受试者 (GD) 中，分级运动期间肾上腺素 (Epi) 和去甲肾上腺素 (NE) 的非线性增加与血乳酸 (La) 平行。在 26 名 GD 运动员中研究了补充葡萄糖 (Glc) 和给药途径对这些关系的影响，这些运动员被随机分配接受 1.3 g/kg Glc，通过缓慢静脉输注 (IV;n= 9)、口服给药 (PO;n= 9) 或在分级最大运动前 2 小时在 1 升水中服用人工加糖安慰剂 (Asp;n= 8)。在正常糖原 (NG) 或 GD 条件下，三组的表现和 La 相似。然而，与 NG 相比，GD 的性能略有改善，并且与 La 曲线向右移动相关。运动前，IV 和 PO 中的血 Glc 浓度较高，但在 IV 中迅速降至最低水平，在 PO 中随时间逐渐下降，而在 Asp 或 NG 中保持稳定。运动开始时，IV 中胰岛素浓度最高，Asp 和 NG 中胰岛素浓度最低，IV 和 PO 中胰岛素浓度迅速下降，但仍高于 Asp 或 NG 中的水平。相比之下，在 Asp 运动期间测量到较高的血清游离脂肪酸水平，三组之间的胰高血糖素或甘油没有显着差异。在耗尽时，IV 中游离和硫酸化 NE 的增加小于 PO 和 Asp 中的增加。相比之下，游离和结合的 Epi 在 IV 中增加最多，而 Asp 的增加最小。多巴胺水平在精疲力尽时静脉注射时增加最多。我们得出的结论是，与葡萄糖调节机制（包括高胰岛素血症）的激活相关的 Epi 和 NE 浓度的变化，在运动前接受口服和静脉注射 Glc 的 GD 受试者在运动期间表现出不同的幅度和时间过程。我们推测，GD 受试者运动前 Glc 急剧增加后胰岛素激增的程度可能对肾上腺依赖性糖原分解和交感神经反应产生分离作用。
Gozal, David, Patrice Thiriet, Jean Marie Cottet-Emard, Dieudonné Wouassi, Emmanuel Bitanga, André Geyssant, Jean Marc Pequignot, and Marcel Sagnol.Glucose administration before exercise modulates catecholaminergic responses in glycogen-depleted subjects.J. Appl. Physiol.82(1): 248–256, 1997.—In glycogen-depleted subjects (GD) a nonlinear increase in epinephrine (Epi) and norepinephrine (NE) parallels blood lactate (La) during graded exercise. The effect of glucose (Glc) supplementation and route of administration on these relationships was studied in 26 GD athletes who were randomly assigned to receive 1.3 g/kg Glc by slow intravenous infusion (IV;n= 9), oral administration (PO;n= 9), or artificially sweetened placebo in 1 liter of water (Asp;n= 8) in the 2 h preceding a graded maximal exercise. Performance and La were similar among the three groups in normal glycogen (NG) or GD conditions. However, slightly improved performances were observed in GD compared with NG and were associated with a shift to the right in La curves. Blood Glc concentrations were higher in IV and PO before exercise, but they rapidly decreased to lowest levels in IV, gradually decreased over time in PO, and remained stable in Asp or NG. Insulin concentrations were highest in IV and lowest in Asp and NG at onset of exercise, rapidly decreasing in IV and PO although remaining at higher levels than in Asp or NG. In contrast, higher serum levels of free fatty acids were measured during exercise in Asp with no significant differences in glucagon or glycerol among the three groups. Free and sulfated NE increases were smaller in IV than in PO and Asp on exhaustion. In contrast, free and conjugated Epi were most increased in IV, with smallest increases in Asp. Dopamine levels were most increased in IV at exhaustion. We conclude that the changes of Epi and NE concentrations, associated with the activation of glucoregulatory mechanisms, including hyperinsulinemia, display different magnitude and time courses during exercise in GD subjects who receive oral vs. intravenous load of Glc before exercise. We speculate that the magnitude of insulin surge after acutely increased Glc before exercise in GD subjects may exert dissociative effects on adrenal-dependent glycogenolysis and on sympathetic responses.
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III 组和 IV 组肌肉传入对葡萄糖调节运动反应的反射控制。
DOI：
10.1152/ajpregu.1994.266.3.r824
发表时间：
1994
期刊：
The American journal of physiology
影响因子：
--
作者：
Vissing,J;Iwamoto,GA;Fuchs,IE;Galbo,H;Mitchell,JH
通讯作者：
Mitchell,JH
影响因子：
3.3
作者：
WALLBERGHENRIKSSON, H;CONSTABLE, SH;HOLLOSZY, JO
通讯作者：
HOLLOSZY, JO
狗血浆中的游离多巴胺：与交感肾上腺活动缺乏关系。
影响因子：
3.3
作者：
J. Pequignot;R. Favier;D. Desplanches;L. Peyrin;R. Flandrois
通讯作者：
R. Flandrois
低肌内糖原不会损害高强度运动表现。
影响因子：
4.1
作者：
J. Symons;I. Jacobs
通讯作者：
I. Jacobs
糖原消耗和先前运动对肌肉力量和耐力能力的相对影响。
影响因子：
3.3
作者：
R. Grisdale;I. Jacobs;E. Cafarelli
通讯作者：
E. Cafarelli