MicroRNA-146a in autoimmunity and innate immune responses.
MicroRNA-146a in autoimmunity and innate immune responses.
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DOI：
10.1136/annrheumdis-2012-202203
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发表时间：
2013-04
影响因子：
27.4
通讯作者：
Satoh M
中科院分区：
文献类型：
--
作者：
Chan EK;Ceribelli A;Satoh M
microRNA（miRNA）是一种长度约为22个核苷酸的单链RNA，通过选择性地结合到3′-非翻译区（UTR）的特定位点来调节靶信使RNA的稳定性。这触发了翻译和mRNA降解的抑制。据估计，大约60%的mRNA受miRNA的控制。在已知的数百种miRNA中，一些被认为是控制单个或多个细胞通路的主调节因子。已知一些miRNA影响发育和细胞分化，而另一些则与免疫和自身免疫性疾病有关。一个非常有趣的例子是miR-146 a，据报道，它在系统性红斑狼疮中下调，在类风湿性关节炎（RA）中上调。一些研究小组最近将注意力集中在RA发病机制中的miRNA上。有趣的是，miR-146 a的表达在RA患者的不同细胞类型和组织中上调。RA中的miRNA也可以被认为是新治疗方法的未来可能靶点。本讨论将集中于目前对miR-146 a在内毒素耐受性和交叉耐受性中的功能的理解，以及它如何有助于调节已知致病性细胞因子（如肿瘤坏死因子α）的过度产生。
MicroRNA (miRNA) are approximately 22 nucleotide single-stranded RNA that regulate the stability of target messenger RNA by selective binding to specific sites at the 3′-untranslated regions (UTR). This triggers repression in translation and mRNA degradation. It has been estimated that approximately 60% of all mRNA are under the control of miRNA. Among the known hundreds of miRNA, some are considered master regulators controlling either a single or multiple cellular pathways. Some miRNA are known to affect development and cell differentiation, while others are implicated in immunity and autoimmune diseases. A very interesting example is miR-146a, which has been reported to be downregulated in systemic lupus erythematosus and upregulated in rheumatoid arthritis (RA). Several groups have recently focused their attention on miRNA in the pathogenesis of RA. Interestingly, the expression of miR-146a is upregulated in different cell types and tissues in RA patients. miRNA in RA could also be considered as possible future targets for new therapeutic approaches. This discussion will focus on the current understanding in the function of miR-146a in endotoxin tolerance and cross-tolerance, and how it may contribute to modulate the overproduction of known pathogenic cytokines, such as tumour necrosis factor α.
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影响因子：
21.3
作者：
Jakymiw, A;Lian, SL;Chan, EKL
通讯作者：
Chan, EKL
影响因子：
4
作者：
Jakymiw, Andrew;Pauley, Kaleb M.;Chan, Edward K. L.
通讯作者：
Chan, Edward K. L.
影响因子：
4
作者：
Guo, Min;Mao, Xiaobo;Zeng, Qiutang
通讯作者：
Zeng, Qiutang
影响因子：
4.5
作者：
Eystathioy, T;Jakymiw, A;Fritzler, MJ
通讯作者：
Fritzler, MJ
DOI：
10.1084/jem.86.1.29
发表时间：
1947-06-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Beeson PB;Technical Assistance of Elizabeth Roberts
通讯作者：
Technical Assistance of Elizabeth Roberts