Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.
Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.
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DOI：
10.1016/j.addr.2014.08.009
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发表时间：
2014-12-15
影响因子：
16.1
通讯作者：
Fischbach C
中科院分区：
文献类型：
--
作者：
Lynch ME;Fischbach C
骨转移是乳腺癌相关死亡的主要原因。然而，骨骼相关的生物力学信号对乳腺癌骨转移的发生、进展和治疗反应的影响在很大程度上是未知的。这篇综述旨在强调骨骼机械信号与乳腺癌骨转移之间可能的功能联系及其对临床结果的贡献。介绍了骨功能适应的生理和生物信号，并讨论了机械负荷和乳腺癌转移在这一过程中的调节作用。根据生物物理设计标准的定义，我们将回顾来自骨生物力学和组织工程领域的体外和体内方法，这些方法可能适合研究乳腺癌骨转移作为各种机械信号的功能。最后，展望与这一新兴领域相关的未来机遇和挑战。
Bone metastasis represents the leading cause of breast cancer related-deaths. However, the effect of skeleton-associated biomechanical signals on the initiation, progression, and therapy response of breast cancer bone metastasis is largely unknown. This review seeks to highlight possible functional connections between skeletal mechanical signals and breast cancer bone metastasis and their contribution to clinical outcome. It provides an introduction to the physical and biological signals underlying bone functional adaptation and discusses the modulatory roles of mechanical loading and breast cancer metastasis in this process. Following a definition of biophysical design criteria, in vitro and in vivo approaches from the fields of bone biomechanics and tissue engineering will be reviewed that may be suitable to investigate breast cancer bone metastasis as a function of varied mechano-signaling. Finally, an outlook of future opportunities and challenges associated with this newly emerging field will be provided.
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DOI：
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影响因子：
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