Influence of Nano-HA Coated Bone Collagen to Acrylic (Polymethylmethacrylate) Bone Cement on Mechanical Properties and Bioactivity.
Influence of Nano-HA Coated Bone Collagen to Acrylic (Polymethylmethacrylate) Bone Cement on Mechanical Properties and Bioactivity.
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DOI：
10.1371/journal.pone.0129018
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Qiu Z
中科院分区：
文献类型：
--
作者：
Li T;Weng X;Bian Y;Zhou L;Cui F;Qiu Z
本研究考察了纳米羟基磷灰石（HA）包被骨胶原（矿化胶原，MC）后聚甲基丙烯酸甲酯（PMMA）骨水泥的力学性能和生物活性。将不同比例的MC添加到PMMA骨水泥中，检测其抗压强度、压缩模量、凝血性能和生物安全性。将MC-PMMA包埋于家兔体内，与MG 63细胞共培养，检测其骨组织相容性和成骨基因表达情况。15.0%（wt）浸渍的MC-PMMA显著降低了抗压模量，但对抗压强度和凝固影响不大。MC-PMMA骨水泥具有生物安全性和良好的骨组织相容性。植入兔股骨6个月后，MC-PMMA的骨水泥界面交联明显高于对照组。成骨相关基因在MC-PMMA中的表达水平明显升高。MC-PMMA具有完善的力学性能、良好的生物安全性和与骨组织良好的生物相容性，具有深远的临床价值。
This research investigated the mechanical properties and bioactivity of polymethylmethacrylate (PMMA) bone cement after addition of the nano-hydroxyapatite(HA) coated bone collagen (mineralized collagen, MC). The MC in different proportions were added to the PMMA bone cement to detect the compressive strength, compression modulus, coagulation properties and biosafety. The MC-PMMA was embedded into rabbits and co-cultured with MG 63 cells to exam bone tissue compatibility and gene expression of osteogenesis. 15.0%(wt) impregnated MC-PMMA significantly lowered compressive modulus while little affected compressive strength and solidification. MC-PMMA bone cement was biologically safe and indicated excellent bone tissue compatibility. The bone-cement interface crosslinking was significantly higher in MC-PMMA than control after 6 months implantation in the femur of rabbits. The genes of osteogenesis exhibited significantly higher expression level in MC-PMMA. MC-PMMA presented perfect mechanical properties, good biosafety and excellent biocompatibility with bone tissues, which has profoundly clinical values.
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DOI：
10.1016/s0883-5403(89)80022-1
发表时间：
1989-09-01
期刊：
The Journal of arthroplasty
影响因子：
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作者：
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DOI：
10.1002/jbm.b.31731
发表时间：
2010-11-01
影响因子：
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