Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease.
Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease.
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CYP2J2 G-50T 多态性与冠心病相关性的 Meta 分析
DOI：
10.18632/oncotarget.19518
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发表时间：
2017-08-29
期刊：
影响因子：
--
通讯作者：
Guo XG
中科院分区：
文献类型：
--
作者：
Chen J;Wang DF;Fu GD;Ding J;Chen LY;Lv JL;Fang J;Yin X;Guo XG
CYP 2 J2 G-50 T多态性与冠状动脉疾病的相关性已被探索，但结果仍存在争议。因此，进行了荟萃分析，以提供这种关联的综合估计。我们选择了10篇文章，包括12项独立的病例对照研究，7063例病例和10,453例对照进行荟萃分析。总的来说，我们在三种遗传模型中发现CYP 2 J2 G-50 T多态性与冠状动脉疾病风险之间存在显著相关性（等位基因模型：比值比（OR）= 1.19，95%可信区间（CI）= 1.05-1.34;纯合子模型：OR = 2.25，95% CI = 1.27-4.01;隐性模型：OR = 2.17，95%CI = 1.22-3.86）。在这三种遗传模型中，当数据按种族分层时，在高加索人中观察到显著相关性，但在亚洲人中未观察到。而CYP 2 J2基因G-50 T多态性在杂合子模型和显性模型中与冠心病风险无显著相关性。总之，我们的荟萃分析表明，CYP 2 J2 G-50 T多态性与冠心病的风险在等位基因，纯合子和隐性模型的高加索人。
The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studies with 7063 cases and 10,453 controls for this meta-analysis. Overall, we found significant associations between the CYP2J2 G-50T polymorphism and coronary artery disease risk in three genetic models (allele model: odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.05–1.34; homozygote model: OR = 2.25, 95% CI = 1.27–4.01; recessive model: OR = 2.17, 95% CI = 1.22–3.86). In these three genetic models, a significant association was observed in Caucasians but not in Asians when the data were stratified by ethnicity. However, no significant associations were found between the CYP2J2 polymorphism G-50T and coronary artery disease risk in heterozygote model and dominant model. In conclusion, our meta-analysis suggested that the CYP2J2 G-50T polymorphism was associated with coronary artery disease risk in the allele, homozygote and recessive models in Caucasians.
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