Age and sex mediated changes in epicardial fat adipokines.
Age and sex mediated changes in epicardial fat adipokines.
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DOI：
10.1016/j.atherosclerosis.2010.06.044
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发表时间：
2010-10
期刊：
影响因子：
5.3
通讯作者：
Santanam N
中科院分区：
文献类型：
--
作者：
Fei J;Cook C;Blough E;Santanam N
衰老是心脏病的一个独立危险因素，它会改变身体脂肪量及其功能。心外膜脂肪对心脏结构和功能具有重要的生理和病理生理作用。本研究调查了衰老是否以性别依赖性方式改变雌性和雄性Fischer 344 × Brown Norway杂交（FBN）大鼠心外膜（EF）和腹部脂肪（AF）衍生介质的丰度。从48只雌性和雄性、年轻（6个月）、老年（26/30个月）和非常老年（30/36个月）FBN大鼠获得EF和AF。使用ELISA、脂肪因子阵列和实时qPCR测量脂肪来源的抗炎和促炎介质。除老年雌性大鼠的甘油三酯和高密度脂蛋白升高以及老年大鼠的循环脂联素显著升高（p< 0.005）外，循环脂质无显著变化。真实的时间PCR结果显示，与6月龄雌性大鼠相比，老龄（26月龄）和极老龄（30月龄）大鼠具有显著较低的EF基因水平：联素（p<0.005），过氧化物酶体增殖物激活受体γ（p<0.01，0.005），IL-6（p<0.01）和派-1（p<0.01，0.01），但在AF中没有。相反，随着年龄的增长，EF组IL-6水平升高（p< 0.005），AF组脂联素和PPARγ水平下降（p <0.005）。这些变化可能归因于脂肪细胞组成或巨噬细胞浸润的差异。总之，衰老对雌性大鼠而不是雄性大鼠的EF衍生介质产生了更深远的影响，这可能有助于解释老年女性心血管疾病风险增加的原因。
Aging, which is an independent risk factor for heart disease, alters body fat mass and its function. Epicardial fat plays an important physiological and pathophysiological role on cardiac structure and function. This study investigated if aging altered the abundance of epicardial (EF) and abdominal fat (AF) derived mediators in a sex dependent manner in female and male Fischer 344 × Brown Norway hybrid (FBN) rats. EF and AF were obtained from 48 female and male, young (6 months), aged (26/30 months) and very aged (30/36 months) FBN rats. Adipose derived anti-inflammatory and pro-inflammatory mediators were measured using ELISA, adipokine array and real-time qPCR. No dramatic changes in circulating lipids other than a higher triglyceride and high density lipoprotein in aged females and a significantly increased circulating adiponectin (p< 0.005) in aged rats were observed. Real time PCR results showed that compared to 6mo old female rats, the aged (26mo) and very aged (30mo) rats had significantly lower levels of EF genes: adiponectin (p<0.005), PPARγ (p<0.01, 0.005), IL-6 (p<0.01) and PAI-1 (p<0.01, 0.01), respectively, but not in AF. In contrast, the male rats exhibited an increase in IL-6 in EF (p< 0.005) but a decrease in adiponectin and PPARγ in AF with aging. These changes might be attributed to differences in adipocyte make-up or macrophage infiltration. In conclusion, aging had a more profound impact on EF derived mediators in female rather than male rats, which might help explain the increased risk to cardiovascular disease seen in older women.
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DOI：
10.1093/gerona/54.11.b492
发表时间：
1999-11-01
影响因子：
5.1
作者：
Turturro, A;Witt, WW;Hart, RW
通讯作者：
Hart, RW
影响因子：
--
作者：
Regitz-Zagrosek, Vera;Lehmkuhl, Elke;Mahmoodzadeh, Shokufeh
通讯作者：
Mahmoodzadeh, Shokufeh
影响因子：
4.9
作者：
Berger, JP
通讯作者：
Berger, JP
影响因子：
4.8
作者：
Fain, JN;Madan, AK;Bahouth, SW
通讯作者：
Bahouth, SW
影响因子：
4.4
作者：
Wu, Dayong;Ren, Zhihong;Meydani, Simin Nikbin
通讯作者：
Meydani, Simin Nikbin