Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea stagnalis).
Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea stagnalis).
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DOI：
10.1093/gerona/glu068
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Kemenes I
中科院分区：
文献类型：
--
作者：
Pirger Z;Naskar S;László Z;Kemenes G;Reglődi D;Kemenes I
随着寿命的延长，非病理性年龄相关性记忆衰退正在影响越来越多的人。然而，有证据表明，与年龄相关的记忆障碍只是暂停，而不是不可逆转地熄灭，老化的神经系统的内在能力可塑性。本研究使用软体动物模型系统，研究人员发现，垂体腺苷酸环化酶激活多肽（PACAP）可以逆转与年龄相关的记忆性能下降。我们前期的研究结果表明，脊椎动物PACAP38及其受体在塘螺（Lymnaea滞螺）的大脑中存在同源物，它对幼龄动物奖赏条件反射后的记忆形成具有必要和指导意义。在这里，我们发现外源性PACAP38促进了老年淋巴细胞的记忆形成，而大脑中内源性PACAP38水平较低。用胰岛素样生长因子-1治疗，在脊椎动物中被证明可以反激活PACAP I型（PAC1）受体，也可以促进老年池塘蜗牛的记忆形成。由于这些多肽的进化保守性质及其在记忆和突触可塑性中的既定作用，它们很有可能也可以作为人类的“记忆恢复”剂。
With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic capacity of the aging nervous system for plasticity. Here, using a molluscan model system, we show that the age-related decline in memory performance can be reversed by administration of the pituitary adenylate cyclase activating polypeptide (PACAP). Our earlier findings showed that a homolog of the vertebrate PACAP38 and its receptors exist in the pond snail (Lymnaea stagnalis) brain, and it is both necessary and instructive for memory formation after reward conditioning in young animals. Here we show that exogenous PACAP38 boosts memory formation in aged Lymnaea, where endogenous PACAP38 levels are low in the brain. Treatment with insulin-like growth factor-1, which in vertebrates was shown to transactivate PACAP type I (PAC1) receptors also boosts memory formation in aged pond snails. Due to the evolutionarily conserved nature of these polypeptides and their established role in memory and synaptic plasticity, there is a very high probability that they could also act as “memory rejuvenating” agents in humans.
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影响因子：
2.4
作者：
Chaudhury, Dipesh;Loh, Dawn H.;Dragich, Joanna M.;Hagopian, Arkady;Colwell, Christopher S.
通讯作者：
Colwell, Christopher S.
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
9.2
作者：
Kemenes, Ildiko;Straub, Volko A.;Benjamin, Paul R.
通讯作者：
Benjamin, Paul R.
DOI：
10.1093/gerona/gls102
发表时间：
2012-06-01
影响因子：
5.1
作者：
Higashi, Yusuke;Sukhanov, Sergiy;Delafontaine, Patrice
通讯作者：
Delafontaine, Patrice
影响因子：
3.3
作者：
Markowska, AL;Mooney, M;Sonntag, WE
通讯作者：
Sonntag, WE