Ventricular function and tissue characterization by cardiac magnetic resonance imaging following hospitalization for multisystem inflammatory syndrome in children: a prospective study.
Ventricular function and tissue characterization by cardiac magnetic resonance imaging following hospitalization for multisystem inflammatory syndrome in children: a prospective study.
复制标题
DOI：
10.1007/s00247-022-05521-5
复制
发表时间：
2023-03
影响因子：
2.3
通讯作者：
Anderson, Brett R.
中科院分区：
文献类型：
--
作者：
DiLorenzo, Michael P.;Farooqi, Kanwal M.;Shah, Amee M.;Channing, Alexandra;Harrington, Jamie K.;Connors, Thomas J.;Martirosyan, Karen;Krishnan, Usha S.;Ferris, Anne;Weller, Rachel J.;Farber, Donna L.;Milner, Joshua D.;Gorelik, Mark;Rosenzweig, Erika B.;Anderson, Brett R.
关键词：
儿童多系统炎症综合征（MIS-C）是严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染后的一种严重危及生命的表现，常表现为急性心功能不全和心源性休克。虽然从急性疾病中恢复良好，但长期心肌影响尚不清楚。比较MIS-C患儿住院后6-9个月的心脏MRI结果与健康对照组的MRI结果，以评估残余心肌疾病。我们前瞻性地对13名MIS-C患儿在住院后6-9个月进行了心脏MRI：其中8名患儿有左心室射血分数（LVEF）<50%、持续症状或心电图（ECG）异常的病史，并接受了临床MRI;其中5名住院期间无心脏异常的患儿接受了研究MRI。我们比较了他们的天然T1和T2映射值与20名正常对照。在13.6岁（四分位距[IQR] 11.9-16.4岁）和住院后8.2个月（IQR 6.8-9.6个月）时进行心脏MRI。12名儿童显示射血分数正常：左心室（LV）57.2%，IQR 56.1-58.4;右心室（RV）53.1%，IQR 52.0-55.7。1例LVEF正常偏低（52%）。与对照组相比，他们有正常的细胞外容积（ECV）和正常的T2和天然T1时间。没有水肿的定性证据。1例患儿有晚期钆增强（LGE），射血分数正常，无水肿，T1和T2时间正常。当根据超声心动图LVEF <55%的病史对MIS-C儿童进行分层时，MRI值没有差异。尽管许多MIS-C患儿急性表现为心功能不全，但6-9个月后的残余心肌损伤似乎很小。长期影响值得进一步研究。
Multisystem inflammatory syndrome in children (MIS-C) is a severe life-threatening manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that often presents with acute cardiac dysfunction and cardiogenic shock. While recovery from acute illness is excellent, the long-term myocardial impact is unknown. To compare cardiac MRI findings in children 6–9 months after their hospitalization with MIS-C against MRI findings in healthy controls to assess for residual myocardial disease. We prospectively performed cardiac MRI on 13 children 6–9 months following their hospitalization with MIS-C: eight of these children had a history of left ventricle ejection fraction (LVEF) < 50%, persistent symptoms, or electrocardiogram (ECG) abnormalities and underwent clinical MRI; five of these children without cardiac abnormalities during their hospitalization underwent research MRIs. We compared their native T1 and T2 mapping values with those of 20 normal controls. Cardiac MRI was performed at 13.6 years of age (interquartile range [IQR] 11.9–16.4 years) and 8.2 months (IQR 6.8–9.6 months) following hospitalization. Twelve children displayed normal ejection fraction: left ventricle (LV) 57.2%, IQR 56.1–58.4; right ventricle (RV) 53.1%, IQR 52.0–55.7. One had low–normal LVEF (52%). They had normal extracellular volume (ECV) and normal T2 and native T1 times compared to controls. There was no qualitative evidence of edema. One child had late gadolinium enhancement (LGE) with normal ejection fraction, no edema, and normal T1 and T2 times. When stratifying children who had MIS-C according to history of LVEF <55% on echocardiography, there was no difference in MRI values. Although many children with MIS-C present acutely with cardiac dysfunction, residual myocardial damage 6–9 months afterward appears minimal. Long-term implications warrant further study.
登录
查看更多内容
DOI：
10.1186/s12968-021-00786-5
发表时间：
2021-07-01
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Webster G;Patel AB;Carr MR;Rigsby CK;Rychlik K;Rowley AH;Robinson JD
通讯作者：
Robinson JD
DOI：
10.1186/s12968-017-0389-8
发表时间：
2017-10-09
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Messroghli DR;Moon JC;Ferreira VM;Grosse-Wortmann L;He T;Kellman P;Mascherbauer J;Nezafat R;Salerno M;Schelbert EB;Taylor AJ;Thompson R;Ugander M;van Heeswijk RB;Friedrich MG
通讯作者：
Friedrich MG
影响因子：
7.5
作者：
Riesenkampff, Eugenie;Messroghli, Daniel R.;Grosse-Wortmann, Lars
通讯作者：
Grosse-Wortmann, Lars
影响因子：
7.5
作者：
Miller, Christopher A.;Naish, Josephine H.;Schmitt, Matthias
通讯作者：
Schmitt, Matthias
影响因子：
8
作者：
Capone, Christine A.;Misra, Nilanjana;Mitchell, Elizabeth
通讯作者：
Mitchell, Elizabeth