The ARID1A, p53 and ß-Catenin statuses are strong prognosticators in clear cell and endometrioid carcinoma of the ovary and the endometrium.
The ARID1A, p53 and ß-Catenin statuses are strong prognosticators in clear cell and endometrioid carcinoma of the ovary and the endometrium.
复制标题
DOI：
10.1371/journal.pone.0192881
复制
发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Mayr D
中科院分区：
文献类型：
--
作者：
Heckl M;Schmoeckel E;Hertlein L;Rottmann M;Jeschke U;Mayr D
本研究的目的是评估 ARID1A、p53、p21、p16 和 ß-Catenin 在子宫内膜样癌、透明细胞卵巢癌和子宫内膜癌中的预后价值。通过组织微阵列和免疫组织化学技术，可对 97 个肿瘤进行 ARID1A、p53、p21、p16 和 ß-Catenin 分析。 32 例为卵巢癌，65 例为子宫内膜癌。子宫内膜样卵巢癌在所有病例中分别有 19% (a)、100% (b)、28.6% (c)、52.4% (d) 和 4.8% (e) 呈 ARID1A (a) 和 p21 (b) 阴性染色，p53 (c) 和 p16 (d) 异常表达，以及 ß-Catenin 阳性核表达 (e)。在透明细胞卵巢癌组中，该比例为 63.6% (a)、100% (b)、81.8% (c)、54.5% (d) 和 0% (e)。对于子宫内膜样子宫癌，这一比例为 75.7% (a)、94.9% (b)、30.5% (c)、52.1% (d) 和 6.8% (e)；对于透明细胞子宫癌，这一比例为 8.6% (a)、100% (b)、50% (c)、100% (d) 和 0% (e)。生存分析表明，ARID1A 阴性表达、p53 异常表达和 β-Catenin 核阳性染色在透明细胞癌和子宫内膜样癌中都是独立的阴性预后因素，无论卵巢或子宫起源如何。 Cox 回归分析再次显示它们是负面预后因素。此外，我们发现子宫内膜样子宫肿瘤中 ARID1A 和 ß-Catenin 表达之间存在显着相关性。分析的妇科癌症显示出与肿瘤抑制相关的蛋白质的独特表达方案。通过分析卵巢癌和子宫内膜癌的透明细胞和子宫内膜样亚型中的肿瘤抑制基因亚组，我们可以得出结论，ARID1A、p53 和 ß-Catenin 是最强的预后因素，并且可以与传统的形态学和临床特征一起用于预后。
The objective of this study was to evaluate the prognostic value of ARID1A, p53, p21, p16 and ß-Catenin in endometrioid and clear cell ovarian and endometrial carcinomas. 97 tumors were available for analysis of ARID1A, p53, p21, p16 and ß-Catenin with the techniques of tissue microarray and immunohistochemistry. 32 were ovarian carcinomas and 65 were endometrial carcinomas. Endometrioid ovarian carcinomas showed negative staining for ARID1A (a) and p21 (b), aberrant expression of p53 (c) and p16 (d) and ß-Catenin positive nuclear expression (e) respectively in 19% (a), 100% (b), 28.6% (c), 52.4% (d) and 4.8% (e) of all cases. In the group of clear cell ovarian carcinomas it was 63.6% (a), 100% (b), 81.8% (c), 54.5% (d) and 0% (e). For endometrioid uterine carcinomas it was 75.7% (a), 94.9% (b), 30.5% (c), 52.1% (d) and 6.8% (e) and for clear cell uterine carcinomas it was 8.6% (a), 100% (b), 50% (c), 100% (d) and 0% (e). Survival analysis showed that negative expression of ARID1A, p53 aberrant expression and ß-Catenin nuclear positive staining are independent negative prognosticators in both, clear cell and endometrioid carcinoma, regardless of ovarian or uterine origin. Cox-Regression analysis showed them again as negative prognostic factors. Furthermore, we found a significant correlation between ARID1A and ß-Catenin expression in endometrioid uterine tumors. The analyzed gynaecological carcinoma showed a distinct expression scheme of proteins that are associated with tumor suppression. We may conclude that ARID1A, p53 and ß-Catenin are the strongest prognostic factors by analyzing a subgroup of tumor suppressor genes in clear cell and endometrioid subtypes of ovarian and endometrial cancer and may be used along with traditional morphological and clinical characteristics for prognosis.
登录
查看更多内容
DOI：
10.1111/j.1525-1438.2006.00494.x
发表时间：
2006-01-01
影响因子：
4.8
作者：
Arai, T;Watanabe, J;Kuramoto, H
通讯作者：
Kuramoto, H
DOI：
10.1002/path.4657
发表时间：
2016-01
期刊：
The Journal of pathology
影响因子：
--
作者：
King CM;Barbara C;Prentice A;Brenton JD;Charnock-Jones DS
通讯作者：
Charnock-Jones DS
影响因子：
64.5
作者：
ELDEIRY, WS;TOKINO, T;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
DOI：
10.1097/01.pgp.0000139711.22158.14
发表时间：
2004-10-01
影响因子：
2.4
作者：
Faleiro-Rodrigues, C;Macedo-Pinto, I;Lopes, CS
通讯作者：
Lopes, CS
影响因子：
5.6
作者：
Alvarez, Teresa;Miller, Ezra;Oliva, Esther
通讯作者：
Oliva, Esther