Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury.
Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury.
复制标题
异甘草酸镁在奥沙利铂诱导的肝损伤模型中具有保肝作用
DOI：
10.3892/ijmm.2018.3787
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发表时间：
2018-10
影响因子：
5.4
通讯作者：
Niu J
中科院分区：
文献类型：
--
作者：
Zou X;Wang Y;Peng C;Wang B;Niu Z;Li Z;Niu J
奥沙利铂是治疗结直肠癌肝转移的核心化疗药物，但奥沙利铂引起的肝损伤增加了围手术期的发病率和死亡率。异甘草酸镁(MGIG)是一种18-α甘草酸立体异构体的镁盐，已证明对毒素和肝炎有保护肝脏的作用。本研究在体内外研究了MgiG对奥沙利铂肝损伤的保护作用。结果表明，MgiG对奥沙利铂诱导的小鼠肝损伤有保护作用，表现为减轻肝组织病理损伤和转氨酶水平。MgiG的保护作用与其对氧化应激、IL-6途径和凝血系统的抑制有关。综上所述，本研究结果提示MgiG在奥沙利铂肝损伤的临床防治中可能具有潜在的应用价值。
Oxaliplatin is a core chemotherapeutic agent used for the treatment of colorectal liver metastasis; however, liver injury caused by oxaliplatin increases the risk of peri-operative morbidity and mortality. Magnesium isoglycyrrhizinate (MgiG) is a magnesium salt of 18-α glycyrrhizic acid stereo-isomer that has demonstrated liver-protective effects against toxins and hepatitis. In the present study, the liver-protective effect of MgiG against oxaliplatin-induced hepatic injury was examined in vitro and in vivo. The results demonstrated that MgiG had a protective effect against oxaliplatin-induced liver injury, as evidenced by the alleviation of hepatic pathological damage and transaminase levels. The protective effect of MgiG was demonstrated to be correlated with inhibition of oxidative stress, the interleukin-6 pathway and the coagulation system. Altogether, the present findings suggested that MgiG may have potential value in the clinical prevention and treatment of oxaliplatin-induced liver injury.
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影响因子：
3.7
作者：
Kelley MR;Jiang Y;Guo C;Reed A;Meng H;Vasko MR
通讯作者：
Vasko MR
影响因子：
4.6
作者：
Li Fei-Yan;Xie Hao;Wang Guang-Ji
通讯作者：
Wang Guang-Ji
影响因子：
2.1
作者：
BRAY, TM;TAYLOR, CG
通讯作者：
TAYLOR, CG
DOI：
10.1016/j.bbrc.2017.11.014
发表时间：
2018-01-01
影响因子：
3.1
作者：
Liu, Miao;Xu, Hanying;Li, Yanchun
通讯作者：
Li, Yanchun
影响因子：
37.8
作者：
ANGLETON, P;CHANDLER, WL;SCHMER, G
通讯作者：
SCHMER, G