Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis.
Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis.
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TCF7L2 基因中的 rs12255372 与 2 型糖尿病的关联：一项荟萃分析。
DOI：
10.1590/1414-431x20132677
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Hu D
中科院分区：
文献类型：
--
作者：
Wang J;Zhang J;Li L;Wang Y;Wang Q;Zhai Y;You H;Hu D
我们的目的是评估 TCF7L2 基因中的 rs12255372 与世界人口 2 型糖尿病 (T2DM) 的关联。我们通过查阅PubMed、Cochrane图书馆和Embase，对2006年至2012年有关rs12255372对T2DM遗传易感性影响的文献进行了调查，然后对所有研究进行了荟萃分析，以评估rs12255372与T2DM之间的关联。共有 33 篇文章，包括 42 项研究（包括 34,076 例病例和 36,192 例对照）被确认符合资格并纳入最终荟萃分析：6 项研究针对欧洲人，14 项针对白种人，17 项针对亚洲人，2 项针对非洲人，3 项针对美国人。总体而言，效应大小如下：对于变异等位基因 T（OR = 1.387，95%CI = 1.351-1.424），对于 TT 基因型（OR = 1.933，95%CI = 1.815-2.057），对于 GT 基因型（OR = 1.363，95%CI = 1.363，95%CI = 1.315-1.413），对于显性模型（OR = 1.425，95%CI = 1.344-1.510），对于隐性模型（OR = 1.659，95%CI = 1.563-1.761）。总之，通过汇集 rs12255372 和 T2DM 基因研究中所有可用的合格数据，我们证实 rs12255372 与全球人群对 T2DM 的易感性显着相关。
Our objective was to evaluate the association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus (T2DM) in the world population. We carried out a survey of the literature about the effect of rs12255372 on genetic susceptibility to T2DM by consulting PubMed, the Cochrane Library, and Embase from 2006 to 2012, and then performed a meta-analysis of all the studies in order to evaluate the association between rs12255372 and T2DM. A total of 33 articles including 42 studies (with 34,076 cases and 36,192 controls) were confirmed to be eligible and were included in the final meta-analysis: 6 studies conducted on Europeans, 14 on Caucasians, 17 on Asians, 2 on Africans, and 3 on Americans. Overall, the effect size was as follows: for the variant allele T (OR = 1.387, 95%CI = 1.351-1.424), for the TT genotype (OR = 1.933, 95%CI = 1.815-2.057), for the GT genotype (OR = 1.363, 95%CI = 1.315-1.413), for the dominant model (OR = 1.425, 95%CI = 1.344-1.510), and for the recessive model (OR = 1.659, 95%CI = 1.563-1.761). In summary, by pooling all available qualified data from genetic studies on rs12255372 and T2DM, we have confirmed that rs12255372 is significantly associated with susceptibility to T2DM in the global population.
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影响因子：
8.2
作者：
Hayashi, T.;Iwamoto, Y.;Maeda, S.
通讯作者：
Maeda, S.
影响因子：
7.7
作者：
Chang, Yi-Cheng;Chang, Tien-Jyun;Chuang, Lee-Ming
通讯作者：
Chuang, Lee-Ming
影响因子：
4.7
作者：
Humphries, Steve E.;Gable, David;Talmud, Philippa J.
通讯作者：
Talmud, Philippa J.
影响因子：
2.1
作者：
Alami FM;Ahmadi M;Bazrafshan H;Tabarraei A;Khosravi A;Tabatabaiefar MA;Samaei NM
通讯作者：
Samaei NM
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N