Resting-state white matter-cortical connectivity in non-human primate brain.
Resting-state white matter-cortical connectivity in non-human primate brain.
复制标题
DOI：
10.1016/j.neuroimage.2018.09.021
复制
发表时间：
2019-01-01
期刊：
影响因子：
5.7
通讯作者：
Gore JC
中科院分区：
文献类型：
--
作者：
Wu TL;Wang F;Li M;Schilling KG;Gao Y;Anderson AW;Chen LM;Ding Z;Gore JC
许多研究已经使用功能性磁共振成像（fMRI）来表征皮质区域之间的功能连接，通过分析在静息状态下的血氧水平依赖（BOLD）信号的相关性。然而，迄今为止，只有少数研究报告了白色物质中的静息状态BOLD信号。尽管如此，近年来出现了越来越多的报告，表明白色物质BOLD信号可以被可靠地检测到，尽管它们的生物物理起源仍然不清楚。此外，最近的研究已经确定了休息状态下来自皮层和特定白色物质束的信号之间的强大相关性。为了进一步验证和解释这些发现，我们研究了一个非人类灵长类动物模型，以调查包裹皮质体积和特定的白色物质束之间的静息态连接模式。我们的研究结果表明，白色和灰质结构之间的静息态连接模式不是随机分布的，但与扩散和组织学衍生的解剖连接有显着的相似之处。这表明，白色物质纤维束和它们所连接的灰质区域之间的静息态BOLD相关性与WM纤维的解剖排列和密度直接相关。我们还测量了不同麻醉水平诱导的不同水平的基线神经活动如何调节这些模式。随着麻醉水平的提高，我们观察到特定的白色物质束和灰质区域之间的相关系数减弱，而连接模式的关键特征保持相似。总的来说，这项研究的结果提供了进一步的证据表明，神经活动是可检测的BOLD功能磁共振成像在灰色和白色物质在整个休息的大脑。灰色和白色物质功能连接的组合使用还可以提供整个大脑的精细全尺度功能分区，以表征其功能结构。
Numerous studies have used functional magnetic resonance imaging (fMRI) to characterize functional connectivity between cortical regions by analyzing correlations in blood oxygenation level dependent (BOLD) signals in a resting state. However, to date, there have been only a handful of studies reporting resting state BOLD signals in white matter. Nonetheless, a growing number of reports has emerged in recent years suggesting white matter BOLD signals can be reliably detected, though their biophysical origins remain unclear. Moreover, recent studies have identified robust correlations in a resting state between signals from cortex and specific white matter tracts. In order to further validate and interpret these findings, we studied a non-human primate model to investigate resting-state connectivity patterns between parcellated cortical volumes and specific white matter bundles. Our results show that resting-state connectivity patterns between white and gray matter structures are not randomly distributed but share notable similarities with diffusion- and histology-derived anatomic connectivities. This suggests that resting-state BOLD correlations between white matter fiber tracts and the gray matter regions to which they connect are directly related to the anatomic arrangement and density of WM fibers. We also measured how different levels of baseline neural activity, induced by varying levels of anesthesia, modulate these patterns. As anesthesia levels were raised, we observed weakened correlation coefficients between specific white matter tracts and gray matter regions while key features of the connectivity pattern remained similar. Overall, results from this study provide further evidence that neural activity is detectable by BOLD fMRI in both gray and white matter throughout the resting brain. The combined use of gray and white matter functional connectivity could also offer refined full-scale functional parcellation of the entire brain to characterize its functional architecture.
登录
查看更多内容
DOI：
10.1023/b:visi.0000043755.93987.aa
发表时间：
2005-02-01
影响因子：
19.5
作者：
Beg, MF;Miller, MI;Younes, L
通讯作者：
Younes, L
影响因子：
2.9
作者：
Fabri, Mara;Polonara, Gabriele;Manzoni, Tullio
通讯作者：
Manzoni, Tullio
影响因子：
2.5
作者：
Iwata, K;Kamo, H;Kitagawa, J
通讯作者：
Kitagawa, J
影响因子：
2.9
作者：
Koyama, T;Kato, K;Mikami, A
通讯作者：
Mikami, A
DOI：
10.1073/pnas.0705791104
发表时间：
2007-11-13
影响因子：
11.1
作者：
Lu, Hanbing;Zuo, Yantao;Stein, Elliot A.
通讯作者：
Stein, Elliot A.