Alterations in oxytocin and vasopressin in men with problematic pornography use: The role of empathy.
Alterations in oxytocin and vasopressin in men with problematic pornography use: The role of empathy.
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用途：共情的作用
DOI：
10.1556/2006.2021.00089
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发表时间：
2022-03-28
影响因子：
7.8
通讯作者：
Feldman, Ruth
中科院分区：
文献类型：
--
作者：
Kor, Ariel;Djalovski, Amir;Potenza, Marc N.;Zagoory-Sharon, Orna;Feldman, Ruth
成瘾行为在临床、遗传、神经生物学和现象学方面与物质成瘾有相似之处。尽管强迫性性行为，尤其是问题性色情使用（PPU）普遍存在，但神经内分泌系统与PPU的关系尚未得到很好的理解。临床前研究表明，在成瘾动物模型中催产素和精氨酸加压素（AVP）功能发生改变，但尚未有人类研究测试它们在PPU中的作用。
参与者包括122名男性；69人报告有PPU，53人是在人口统计学上匹配的无PPU参与者。在基线时测量血浆催产素和AVP水平以及催产素与AVP的平衡。在基线时以及对四个描绘中性/积极社交场景的视频做出反应时评估唾液催产素。参与者报告同理心和精神症状。
有PPU的男性基线血浆AVP水平升高，催产素与加压素的比率表明AVP占优势。有PPU的男性在面对中性/积极的社会刺激时催产素增加幅度更大。有PPU的男性同理心倾向降低，这种同理心的降低介导了催产素与色情相关的性欲亢进之间的联系。结构方程模型揭示了通向色情相关性欲亢进的三条独立路径；两条直接路径是通过AVP增加和较高的精神症状，一条间接路径是从催产素到色情相关性欲亢进，由同理心降低所介导。
这些发现首次表明维持哺乳动物依恋的神经肽在色情相关性欲亢进的病理生理学中起作用，并描述了一种神经生物学机制，通过该机制催产素 - AVP系统和精神症状可能会降低同理心并导致色情相关的性欲亢进。
Addictive behaviors share clinical, genetic, neurobiological and phenomenological parallels with substance addictions. Despite the prevalence of compulsive sexual behaviors, particularly problematic pornography use (PPU), how neuroendocrine systems relate to PPU is not well understood. Preclinical studies demonstrate alterations in oxytocin and arginine vasopressin (AVP) function in animal models of addiction, but no human study has tested their involvement in PPU. Participants included 122 males; 69 reported PPU, and 53 were demographically-matched participants without PPU. Plasma oxytocin and AVP levels and oxytocin-to-AVP balance were measured at baseline. Salivary oxytocin was assessed at baseline and in response to four videos depicting neutral/positive social encounters. Participants reported on empathy and psychiatric symptoms. Baseline plasma AVP levels were elevated in men with PPU, and the ratio of oxytocin-to-vasopressin suggested AVP dominance. Men with PPU reacted with greater oxytocin increases to presentation of neutral/positive social stimuli. Decreased empathic tendencies were found in men with PPU, and this reduced empathy mediated links between oxytocin and pornography-related hypersexuality. Structural equation modeling revealed three independent paths to pornography-related hypersexuality; two direct paths via increased AVP and higher psychiatric symptoms and one indirect path from oxytocin to pornography-related hypersexuality mediated by diminished empathy. Findings are among the first to implicate neuropeptides sustaining mammalian attachment in the pathophysiology of pornography-related hypersexuality and describe a neurobiological mechanism by which oxytocin-AVP systems and psychiatric symptomatology may operate to reduce empathy and lead to pornography-related hypersexuality.
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影响因子：
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作者：
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影响因子：
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