Depressed height gain of children associated with intrauterine exposure to polycyclic aromatic hydrocarbons (PAH) and heavy metals: the cohort prospective study.
Depressed height gain of children associated with intrauterine exposure to polycyclic aromatic hydrocarbons (PAH) and heavy metals: the cohort prospective study.
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与子宫内暴露于多环芳烃（PAH）和重金属相关的儿童的降低高度增长：同胞前瞻性研究。
DOI：
10.1016/j.envres.2014.08.047
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发表时间：
2015-01
影响因子：
8.3
通讯作者：
Jacek, Ryszard
中科院分区：
文献类型：
--
作者：
Jedrychowski, Wieslaw A.;Perera, Frederica P.;Majewska, Renata;Mrozek-Budzyn, Dorota;Mroz, Elzbieta;Roen, Emily L.;Sowa, Agata;Jacek, Ryszard
胎儿暴露于环境有毒物质可能会影响儿童的发育，并对健康产生长期影响。这项研究验证了一个假设，即儿童期身高增加与产前暴露于空气中的多环芳烃（PAH）和重金属（铅和汞）有关。研究样本包括379名不吸烟母亲所生的儿童，在9年的随访期内共进行了2011次身高测量。产前空气中的PAH暴露进行了评估，个人空气监测的母亲在怀孕中期和重金属测定脐带血。在3岁的住宅空气监测，以评估空气中的PAH的水平，并在5岁的毛细血管血液中的重金属水平进行了测量。在一般估计方程（GEE）模型中，针对广泛的相关协变量，调整了产前PAH暴露对随访期间身高生长的影响估计值。产前暴露于空气中的PAH与身高增长呈显著负相关，当PAH水平高于34.7 ng/m3时，身高增长显著下降1.1 cm（coeff. =-1.07，p = 0.040）。虽然产前铅暴露与身高限制没有显著相关性，但汞的影响与脐带血汞浓度高于1.2 ug/dL呈负相关（coeff. =-1.21，p = 0.020），观察到的产前PAH暴露对儿童期身高增加的负面影响主要是通过与妊娠期间母体PAH暴露相关的较短出生长度介导的。出生时未发现与产前汞暴露相关的身高增加缺陷，但在以后的年龄，身高增长明显减慢。
Fetal exposure to environmental toxicants may program the development of children and have long-lasting health impacts. The study tested the hypothesis that depressed height gain in childhood is associated with prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAH) and heavy metals (lead and mercury). The study sample comprised 379 children born to non-smoking mothers among whom a total of 2011 height measurements were carried out over the 9-year follow-up period. Prenatal airborne PAH exposure was assessed by personal air monitoring of the mother in the second trimester of pregnancy and heavy metals were measured in cord blood. At the age of 3 residential air monitoring was done to evaluate the level of airborne PAH, and at the age 5 the levels of heavy metals were measured in capillary blood. The effect estimates of prenatal PAH exposure on height growth over the follow-up were adjusted in the General Estimated Equation (GEE) models for a wide set of relevant covariates. Prenatal exposure to airborne PAH showed a significant negative association with height growth, which was significantly decreased by 1.1 cm at PAH level above 34.7 ng/m3 (coeff. = − 1.07, p = 0.040). While prenatal lead exposure was not significantly associated with height restriction, the effect of mercury was inversely related to cord blood mercury concentration above 1.2 ug/dL (coeff. = −1.21, p = 0.020), The observed negative impact of prenatal PAH exposure on height gain in childhood was mainly mediated by shorter birth length related to maternal PAH exposure during pregnancy. The height gain deficit associated with prenatal mercury exposure was not seen at birth, but the height growth was significantly slower at later age.
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