Antenatal corticosteriods decrease forced vital capacity in infants born fullterm.
Antenatal corticosteriods decrease forced vital capacity in infants born fullterm.
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DOI：
10.1002/ppul.24941
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发表时间：
2020-10
影响因子：
3.1
通讯作者：
Tepper RS
中科院分区：
文献类型：
--
作者：
Bandyopadhyay A;Slaven JE;Evrard C;Tiller C;Haas DM;Tepper RS
对先兆早产孕妇进行产前皮质类固醇 (ACS) 是标准的产科护理，可减少新生儿呼吸窘迫综合征和相关的呼吸系统疾病。虽然 ACS 刺激胎儿肺中表面活性剂的产生，但 ACS 对肺随后生长和发育的影响尚不清楚。新生儿期以外的后续研究主要限于肺活量测定，并且大多数评估的受试者都是早产的。据我们所知，尚无研究评估 ACS 暴露后婴儿或成人的气道和实质功能。我们假设 ACS 会损害肺部生长，并进行了婴儿肺功能测试，其中包括肺活量测定、肺泡容积 (VA) 和肺扩散 (DL)。作为一项试点研究，我们将评估范围仅限于母亲因先兆早产而接受 ACS 治疗的婴儿，但随后又进行足月分娩。这种方法评估了更同质的人群并消除了早产的混杂影响。我们评估了 36 名 4-12 个月大的足月婴儿； 17 名婴儿有 ACS 暴露，19 名婴儿没有 ACS 暴露。与未暴露于 ACS 的婴儿相比，暴露于 ACS 的婴儿的 FVC 显着较低（250 毫升 vs. 313 毫升；p = 0.0075）。 ACS 暴露组的 FEV0.5 往往较低（205 毫升 vs 237 毫升；p = 0.075）。两组之间的 VA 和 DL 没有差异。这些发现表明 ACS 可能会损害肺实质的后续生长。
Antenatal corticosteroids (ACS) administration to pregnant women for threatened preterm labor is standard obstetric care to reduce neonatal respiratory distress syndrome and the associated respiratory morbidity. While ACS stimulates surfactant production in the fetal lung, the effects of ACS upon the subsequent growth and development of the lung are unclear. Follow-up studies outside of the neonatal period have been primarily limited to spirometry, and most subjects evaluated were born prematurely. To our knowledge, no study has assessed both airway and parenchymal function in infants or adults following ACS exposure. We hypothesized that ACS impairs lung growth and performed infant pulmonary function testing, which included spirometry, alveolar volume (VA) and lung diffusion (DL). As a pilot study, we limited our assessment to infants whose mothers received ACS for threatened preterm labor, but then proceeded to full term delivery. This approach evaluated a more homogenous population and eliminated the confounding effects of preterm birth. We evaluated 36 full-term infants between 4–12 months of age; 17 infants had ACS exposure and 19 infants had no ACS exposure. Infants exposed to ACS had a significantly lower FVC compared to non-ACS exposed infants (250 vs. 313 ml; p = 0.0075). FEV0.5 tended to be lower for the ACS exposed group (205 vs. 237 ml; p = 0.075). VA and DL did not differ between the two groups. These findings suggest that ACS may impair subsequent growth of the lung parenchyma.
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DOI：
10.1164/rccm.200908-1190oc
发表时间：
2010-05-15
影响因子：
24.7
作者：
Balinotti, Juan E.;Chakr, Valentina C.;Tepper, Robert S.
通讯作者：
Tepper, Robert S.
影响因子：
3.1
作者：
Castillo, Andres;Llapur, Conrado J.;Tepper, Robert S.
通讯作者：
Tepper, Robert S.
影响因子：
2.9
作者：
Nixon, P. A.;Washburn, L. K.;O'Shea, T. M.
通讯作者：
O'Shea, T. M.
影响因子：
3.1
作者：
McEvoy, C;Bowling, S;Durand, N
通讯作者：
Durand, N
影响因子：
3.6
作者：
Okajima, S;Matsuda, T;Fujimoto, S
通讯作者：
Fujimoto, S