Preservation of Hearing Following Cochlear Implantation Using Different Steroid Therapy Regimens: A Prospective Clinical Study.
Preservation of Hearing Following Cochlear Implantation Using Different Steroid Therapy Regimens: A Prospective Clinical Study.
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DOI：
10.12659/msm.906210
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发表时间：
2018-04-22
期刊：
影响因子：
--
通讯作者：
Skarżyński H
中科院分区：
文献类型：
--
作者：
Skarżyńska MB;Skarżyński PH;Król B;Kozieł M;Osińska K;Gos E;Skarżyński H
一项前瞻性临床研究进行了评估不同方案的类固醇治疗和听力保存后的人工耳蜗植入。研究参与者年龄≥18岁，计算机断层扫描（CT）测量耳蜗管长度≥27.1 mm，听力声级范围为10-120分贝（dB），声音频率为125-250赫兹（Hz）；35 - 120db声级，500 - 1000hz频率；75-120分贝的声级和2000 - 8000赫兹的频率。研究排除标准包括有类固醇治疗禁忌症的疾病或增加类固醇作用的药物。人工耳蜗植入术患者分为三个治疗组：静脉（IV）类固醇治疗（标准类固醇治疗）；口服和静脉类固醇联合治疗（延长类固醇治疗）；另设对照组（人工耳蜗植入，不使用类固醇治疗）。根据HEARRING Network制定的公式，根据术前和术后平均听力阈值，采用纯音测听法建立听力保护。共有36名患者参与了这项研究。所有病例均采用圆窗入路植入人工耳蜗电极，电极直长28mm。口服和静脉类固醇联合治疗（延长类固醇治疗）的患者与静脉（IV）类固醇治疗（标准类固醇治疗）和对照组的患者相比，效果更好。长期使用口服和静脉注射类固醇治疗稳定听力阈值和保留听力的成年患者耳蜗植入术后。
A prospective clinical study was conducted to assess different regimens of steroid therapy and preservation of hearing following cochlear implantation. Study participants were ≥18 years-of-age, with a cochlear duct length ≥27.1 mm measured by computed tomography (CT), with hearing sound levels in the range of 10–120 decibels (dB) and sound frequencies of 125–250 hertz (Hz); sound levels of 35–120 dB and frequencies of 500–1,000 Hz; sound levels of 75–120 dB and frequencies of 2,000–8,000 Hz. Study exclusion criteria included diseases with contraindications for steroid therapy or medications that increased the effects of steroids. Patients had cochlear implantation and were divided into three treatment groups: intravenous (IV) steroid therapy (standard steroid therapy): combined oral and IV steroid therapy (prolonged steroid therapy); and a control group (cochlear implantation without steroid therapy). Hearing preservation was established by pure tone audiometry based on the pre-operative and postoperative average hearing thresholds according to the formula developed by the HEARRING Network. There were 36 patients included in the study. In all cases, the cochlear implant electrode was inserted via the round window approach with a straight electrode length of 28 mm. Patients with combined oral and IV steroid therapy (prolonged steroid therapy) had better results when compared with patients with intravenous (IV) steroid therapy (standard steroid therapy) and the control group. Prolonged steroid therapy using combined oral and IV steroids stabilized hearing thresholds and preserved hearing in adult patients following cochlear implantation.
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影响因子：
16.1
作者：
Swan, Erin E. Leary;Mescher, Mark J.;Sewell, William F.;Tao, Sarah L.;Borenstein, Jeffrey I.
通讯作者：
Borenstein, Jeffrey I.
影响因子：
2.6
作者：
Alles, M. J. R. C.;Gaag, M. A. der;Stokroos, R. J.
通讯作者：
Stokroos, R. J.
影响因子：
2.6
作者：
Paulson, David P.;Abuzeid, Waleed;Li, Daqing
通讯作者：
Li, Daqing
影响因子：
2.5
作者：
Saito, T;Zhang, ZJ;Saito, H
通讯作者：
Saito, H
DOI：
10.1016/j.ijporl.2015.08.040
发表时间：
2015-11-01
影响因子：
1.5
作者：
Skarzynski, Henryk;Lorens, Artur;Skarzynski, Piotr H.
通讯作者：
Skarzynski, Piotr H.