Inner ear drug delivery for auditory applications.
Inner ear drug delivery for auditory applications.
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DOI：
10.1016/j.addr.2008.08.001
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发表时间：
2008-12-14
影响因子：
16.1
通讯作者：
Borenstein, Jeffrey I.
中科院分区：
文献类型：
--
作者：
Swan, Erin E. Leary;Mescher, Mark J.;Sewell, William F.;Tao, Sarah L.;Borenstein, Jeffrey I.
许多内耳疾病不能通过全身给药得到充分治疗。在生理上与血脑屏障相似，存在一种血-耳屏障，它限制了能够离开血液循环并进入内耳细胞的分子的浓度和大小。然而，对新疗法和给药系统的研究在开发局部给药到内耳的方法方面取得了重大进展。鼓室内方法将治疗药物输送到中耳，依靠组织渗透进入内耳结构，而鼓室内方法能够直接将药物插入内耳。人们正在探索创新的药物输送系统，以治疗各种内耳疾病，如耳毒性、突发性感音神经性耳聋、自身免疫性内耳疾病，以及保护神经元和再生感觉细胞。
Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-cochlear barrier exists, similar physiologically to the blood-brain barrier, which limits the concentration and size of molecules able to leave the circulation and gain access to the cells of the inner ear. However, research in novel therapeutics and delivery systems has led to significant progress in the development of local methods of drug delivery to the inner ear. Intratympanic approaches, which deliver therapeutics to the middle ear, rely on permeation through tissue for access to the structures of the inner ear, whereas intracochlear methods are able to directly insert drugs into the inner ear. Innovative drug delivery systems to treat various inner ear ailments such as ototoxicity, sudden sensorineural hearing loss, autoimmune inner ear disease, and for preserving neurons and regenerating sensory cells are being explored.
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影响因子：
2.8
作者：
BROWN, JN;MILLER, JM;NUTTALL, AL
通讯作者：
NUTTALL, AL
影响因子：
1.4
作者：
Duan, Maoli;Chen, Zhiqiang;Ruan, Runsheng
通讯作者：
Ruan, Runsheng
影响因子：
2.1
作者：
Chandrasekhar, SS
通讯作者：
Chandrasekhar, SS
影响因子：
3.3
作者：
Coleman, B.;Hardman, J.;Shepherd, R.
通讯作者：
Shepherd, R.
影响因子：
2.6
作者：
Endo, T;Nakagawa, T;Ito, J
通讯作者：
Ito, J