Lateral parietal contributions to memory impairment in posterior cortical atrophy.
Lateral parietal contributions to memory impairment in posterior cortical atrophy.
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DOI：
10.1016/j.nicl.2018.07.005
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Butler C
中科院分区：
文献类型：
--
作者：
Ahmed S;Loane C;Bartels S;Zamboni G;Mackay C;Baker I;Husain M;Thompson S;Hornberger M;Butler C
后皮质萎缩（PCA）是一种神经退行性综合征，其特征是视觉空间和感知功能的进行性损害。最近的研究结果表明，记忆功能也可能在疾病的早期受到损害。在这项研究中，我们研究了PCA记忆障碍的神经基础，并假设相关性将观察到顶叶皮层，而不是经典的内侧颞叶记忆结构。18例PCA患者、15例典型阿尔茨海默病（tAD）患者和21例健康对照者接受了Rey听觉言语学习测验（RAVLT）词表和MRI的记忆测试。基于体素的形态测量（VBM）被用来确定顶叶和内侧颞叶与记忆表现相关的区域。与对照组相比，PCA患者在学习、即时和延迟回忆以及对RAVLT的识别方面受损。PCA组的学习率和即时回忆显著优于tAD组，而延迟回忆无差异。患者组之间的识别记忆也没有统计学差异，但PCA患者的假阳性错误明显多于tAD患者。PCA患者的VBM分析显示，右侧缘上回、右侧角回和左侧中央后回的总学习能力与灰质密度之间存在显著相关性。左侧中央后回也与即时回忆、延迟回忆和再认记忆显著相关。在内侧颞叶中未检测到相关性。研究结果提供了新的证据，早期言语记忆障碍是经常观察到的PCA，并与侧顶叶结构的损害。这些结果对PCA的诊断和管理具有重要意义。PCA患者在学习、回忆和再认记忆方面存在障碍。在疾病的早期阶段，缺陷是明显的。记忆障碍与侧顶叶结构的损伤有关。在内侧颞叶中未检测到相关性。
Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterised by progressive impairment in visuospatial and perceptual function. Recent findings show that memory functioning can also be compromised early in the course of disease. In this study, we investigated the neural basis of memory impairment in PCA, and hypothesised that correlations would be observed with parietal cortex rather than classic medial temporal memory structures. Eighteen PCA patients, 15 typical Alzheimer's disease (tAD) patients and 21 healthy controls underwent memory testing with the Rey Auditory Verbal Learning Test (RAVLT) word list and MRI. Voxel-based morphometry (VBM) was used to identify regions in the parietal and medial temporal lobes that correlated with memory performance. Compared with controls, PCA patients were impaired at learning, immediate and delayed recall and recognition of the RAVLT. Learning rate and immediate recall was significantly better in PCA compared to tAD, whereas there was no difference in delayed recall. Recognition memory also was not statistically different between patient groups, but PCA patients made significantly more false positive errors than tAD patients. VBM analysis in the PCA patients revealed a significant correlation between total learning and grey matter density in the right supramarginal gyrus, right angular gyrus and left postcentral gyrus. The left post central gyrus also significantly correlated with immediate and delayed recall and with recognition memory. No correlations were detected in the medial temporal lobe. The findings provide novel evidence that early verbal memory impairment is frequently observed in PCA, and is associated with damage to lateral parietal structures. The results have implications for the diagnosis and management of PCA. PCA patients were impaired in learning, recall and recognition memory. Deficits were evident in the early stages of disease. Memory impairment was associated with damage to lateral parietal structures. No correlations were detected in the medial temporal lobe.
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