Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study.
Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study.
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就寝时间、夜尿频率和膀胱尿路上皮癌的风险：病例对照研究
DOI：
10.7150/jca.21555
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发表时间：
2017
影响因子：
3.9
通讯作者：
Shi B
中科院分区：
文献类型：
--
作者：
Cui J;Bo Q;Zhang N;Chen S;Yu M;Wang S;Han J;Chen P;Zhang D;Zhu Y;Shi B
目的：在中国人群中进行的一项基于医院的病例对照研究中，阐明液体摄入至上床时间和排尿频率对膀胱癌风险的潜在作用。材料与方法：407例组织学诊断为膀胱癌的患者和400例匹配的对照组入组本研究。采用条件Logistic回归模型计算OR值和95%可信区间（CI）。结果如下：校正潜在混杂因素后，补液至卧床时间与BCa风险降低相关，OR为0.586（95%CI = 0.375-0.916，≤1h）和0.257（95%CI = 0.162-0.407，>1h）。与无排尿次数的受试者相比，排尿次数较多（≥2次）的受试者BCa的校正OR为2.268（95%CI = 1.481-3474）。结论：长时间卧床补液对BCa风险具有较强的保护作用，尤其是在≥2次卧床频率的患者中。这些结果为识别高危人群和改变他们的行为和生活方式提供了证据。
Objectives: To clarify the potential role of fluid intake-to-bed time and nocturia frequency on bladder cancer risk in a hospital-based case-control study with Chinese people. Materials and Methods: Four hundred and seven patients with histologically diagnosed bladder cancer and 400 matched controls were enrolled in this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression model. Results: After adjustment for potential confounders, the fluid intake-to-bed time was associated with a decreased risk of BCa, with an OR of 0.586 (95% CI= 0.375-0.916, ≤1h) and 0.257 (95% CI= 0.162-0.407, >1h). The adjusted OR of BCa for subjects with more nocturia frequency (≥2 times) was 2.268 (95 % CI= 1.481-3474), compared to those with no nocturia. Conclusion: We suggested strong protective effect of long fluid intake-to-bed time on BCa risk, especially in ones with ≥2 times nocturia frequency. These results provide evidence for identifying high-risk individuals and modifying their behaviors and lifestyle.
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8.8
作者：
Wang J;Wu X;Kamat A;Barton Grossman H;Dinney CP;Lin J
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168.9
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Danaei, G;Vander Hoorn, S;Ezzati, M
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Ezzati, M
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CLAUDE, J;KUNZE, E;SCHUBERT, H
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SCHUBERT, H
影响因子：
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Auvinen, Anssi
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van Kerrebroeck, P;Abrams, P;Weiss, J
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Weiss, J