Fluid intake, genetic variants of UDP-glucuronosyltransferases, and bladder cancer risk.
Fluid intake, genetic variants of UDP-glucuronosyltransferases, and bladder cancer risk.
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DOI：
10.1038/bjc.2013.190
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发表时间：
2013-06-11
影响因子：
8.8
通讯作者：
Lin J
中科院分区：
文献类型：
--
作者：
Wang J;Wu X;Kamat A;Barton Grossman H;Dinney CP;Lin J
关于液体消耗及其与膀胱癌相关性的研究结果一直不一致。很少有研究考虑可能与所消耗的液体类型相互作用的遗传变异的修饰效应。UDP-葡萄糖醛酸转移酶（UGT）是一种膜结合酶，可催化疏水底物转化为水溶性更高的葡萄糖醛酸苷，以促进肾脏或胆汁排泄。UGT中的遗传变异是否可以调节液体摄入量和膀胱癌之间的关联尚未研究。我们对1007例经组织病理学证实的膀胱癌患者和1299例健康对照进行了病例对照研究。通过面对面访谈收集液体摄入量和流行病学数据。采用多因素非条件Logistic回归估计比值比（OR）和95%置信区间（95%CI）。校正潜在混杂因素后，高液体摄入量（每天2789 ml vs <1696 ml）使膀胱癌风险增加41%（OR=1.41; 95%CI =1.10-1.81）。特定的液体，如普通软饮料和无咖啡因咖啡也与风险增加有关，而茶，葡萄酒和白酒与风险降低有关。在UGT基因家族的83个单核苷酸多态性中，有18个与膀胱癌风险显著相关。最显著的一个是rs7571337，变异基因型使风险降低29%（OR=0.71; 95%CI =0.56-0.90）。总的和特定的液体摄入量与研究人群中的膀胱癌风险相关，UGT基因的遗传变异可以调节这种影响。这些结果有助于识别高风险个体，并对膀胱癌预防具有重要意义。
Results of studies of fluid consumption and its association with bladder cancer have been inconsistent. Few studies have considered modification effects from genetic variants that may interact with the type of consumed fluids. UDP-glucuronosyltransferases (UGTs), which are membrane-bound conjugating enzymes, catalyse the transformation of hydrophobic substrates to more water-soluble glucuronides to facilitate renal or biliary excretion. Whether genetic variants in UGTs could modulate the association between fluid intake and bladder cancer has not been studied. We conducted a case–control study with 1007 patients with histopathologically confirmed bladder cancer and 1299 healthy matched controls. Fluid intake and epidemiologic data were collected via in-person interview. Multivariate unconditional logistic regression was used to estimate odds ratios (ORs) and the 95% confidence intervals (95% CI). After adjustment for potential confounders, high quantity of total fluid intake (⩾2789 vs <1696 ml per day) conferred a 41% increased risk of bladder cancer (OR=1.41; 95% CI=1.10–1.81). Specific fluids such as regular soft drinks and decaffeinated coffee were also associated with increased risks, whereas tea, wine, and liquor were associated with decreased risks. Among 83 single-nucleotide polymorphisms in the UGT gene family, 18 were significantly associated with bladder cancer risk. The most significant one was rs7571337, with the variant genotype conferring a 29% reduction in risk (OR=0.71; 95% CI=0.56–0.90). Total and specific fluid intakes are associated with bladder cancer risk in the study population and that genetic variants of UGT genes could modulate the effects. These results facilitate identification of high-risk individuals and have important implications in bladder cancer prevention.
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影响因子：
158.5
作者：
Michaud, DS;Spiegelman, D;Giovannucci, EL
通讯作者：
Giovannucci, EL
影响因子：
5
作者：
CLAUDE, J;KUNZE, E;SCHUBERT, H
通讯作者：
SCHUBERT, H
影响因子：
2.7
作者：
Iida, Katsuyuki;Mimura, Junsei;Yamamoto, Masayuki
通讯作者：
Yamamoto, Masayuki
影响因子：
6.4
作者：
Jiang, Xuejuan;Castelao, J. Esteban;Gago-Dominguez, Manuela
通讯作者：
Gago-Dominguez, Manuela
影响因子：
5.7
作者：
Kurahashi, Norie;Inoue, Manami;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro