Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism.
Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism.
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DOI：
10.1186/1742-2094-11-69
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发表时间：
2014-04-03
影响因子：
9.3
通讯作者：
Mostafa GA
中科院分区：
文献类型：
--
作者：
AL-Ayadhi LY;Mostafa GA
越来越多的证据表明，一些自闭症患者的自身免疫现象可能代表了这种疾病中存在改变或不适当的免疫反应。核小体在某些自身免疫介导的组织损伤中诱导抗体应答的作用可能为治疗提供新的靶点。由于缺乏研究调查自闭症的全身性自身抗体的频率，我们是第一个调查的频率在一组自闭症儿童的抗核小体特异性抗体。血清抗核小体特异性抗体测定ELISA在60名自闭症儿童，年龄在3至12岁之间，与60名健康儿童相比。自闭症的严重程度使用儿童自闭症评定量表（汽车）进行评估。孤独症儿童血清抗核小体特异性抗体水平显著高于健康儿童（P <0.001）。抗核小体特异性抗体阳性率为46.7%。有自身免疫家族史的孤独症患儿（40%）血清抗核小体特异性抗体阳性率（83.3%）显著高于无自身免疫家族史的患儿（22.2%，P <0.001）。抗核小体特异性抗体的血清水平增加，在一些自闭症儿童。然而，这些数据应谨慎对待，直到更大的受试者人群进行进一步的研究，以确定这些抗体是否在自闭症儿童亚组中诱导自身免疫中发挥作用。免疫疗法在自闭症儿童中的作用也应该研究。
Increasing evidence of autoimmune phenomena in some individuals with autism could represent the presence of altered or inappropriate immune responses in this disorder. The role of the nucleosome in the induction of antibody response in some autoimmune-mediated tissue damage may provide novel targets for treatment. Due to the paucity of studies investigating the frequency of systemic auto-antibodies in autism, we are the first to investigate the frequency of antinucleosome-specific antibodies in a group of autistic children. Serum antinucleosome-specific antibodies were measured by ELISA in 60 autistic children, between the ages of 3 and 12 years, in comparison to 60 healthy children. Autistic severity was assessed using the Childhood Autism Rating Scale (CARS). Autistic children had significantly higher serum antinucleosome-specific antibodies than healthy children (P <0.001). The seropositivity of antinucleosome-specific antibodies was found in 46.7% of autistic children. Autistic children with a family history of autoimmunity (40%) had a significantly higher frequency of serum antinucleosome-specific antibodies (83.3%) than patients without such a history (22.2%, P <0.001). Serum levels of antinucleosome-specific antibodies were increased in some autistic children. However, these data should be treated with caution until further investigations are performed with a larger subject population to determine whether these antibodies have a role in the induction of autoimmunity in a subgroup of autistic children. The role of immunotherapy in children with autism should be also studied.
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影响因子：
9.3
作者：
Al-Ayadhi LY;Mostafa GA
通讯作者：
Mostafa GA
影响因子：
3.8
作者：
Lee, Li-Ching;Zachary, Andrea A.;Zimmerman, Andrew W.
通讯作者：
Zimmerman, Andrew W.
影响因子：
--
作者：
Lorenz, HM;Grunke, M;Kalden, JR
通讯作者：
Kalden, JR
影响因子：
3.3
作者：
Mostafa, Gehan A.;Shehab, Abeer A.;Al-Ayadhi, Laila Y.
通讯作者：
Al-Ayadhi, Laila Y.
影响因子：
3.3
作者：
Mostafa, Gehan A.;Shehab, Abeer A.
通讯作者：
Shehab, Abeer A.