Schistosomiasis as a disease of stem cells.
Schistosomiasis as a disease of stem cells.
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DOI:
10.1016/j.gde.2016.06.010
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发表时间:
2016-10
影响因子:
4
通讯作者:
Collins, James J., III
中科院分区:
文献类型:
--
作者:
Wendt, George R.;Collins, James J., III
Schistosomiasis is a devastating parasitic disease caused by flatworms of the genus Schistosoma. The complex life cycles and developmental plasticity of these parasites have captured the attention of parsitologists for decades, yet little is known on the molecular level about the developmental underpinnings that have allowed these worms to thrive as obligate parasites. Here, we describe basic schistosome biology and highlight how understanding the functions of stem cells in these worms will transform our understanding of these parasites. Indeed, we propose that schistosomiasis is fundamentally as disease of stem cells. We hope this review will attract new interest in the basic developmental biology of these important organisms.
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