Schistosomiasis as a disease of stem cells.

Schistosomiasis as a disease of stem cells.
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DOI:
10.1016/j.gde.2016.06.010
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发表时间:
2016-10
影响因子:
4
通讯作者:
Collins, James J., III
Collins, James J., III
中科院分区:
生物学2区
文献类型:
--
作者:
Wendt, George R.;Collins, James J., III

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血吸虫病是由血吸虫属扁虫引起的一种毁灭性寄生虫病。几十年来,这些寄生虫复杂的生命周期和发育可塑性引起了寄生虫学家的关注,但在分子水平上,人们对这些蠕虫作为专性寄生虫蓬勃发展的发育基础知之甚少。在这里,我们描述了基本的血吸虫生物学,并强调了解这些蠕虫干细胞的功能将如何改变我们对这些寄生虫的理解。事实上,我们认为血吸虫病从根本上来说是干细胞疾病。我们希望这篇综述能够引起人们对这些重要生物体的基本发育生物学的新兴趣。
Schistosomiasis is a devastating parasitic disease caused by flatworms of the genus Schistosoma. The complex life cycles and developmental plasticity of these parasites have captured the attention of parsitologists for decades, yet little is known on the molecular level about the developmental underpinnings that have allowed these worms to thrive as obligate parasites. Here, we describe basic schistosome biology and highlight how understanding the functions of stem cells in these worms will transform our understanding of these parasites. Indeed, we propose that schistosomiasis is fundamentally as disease of stem cells. We hope this review will attract new interest in the basic developmental biology of these important organisms.
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