Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake.
Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake.
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DOI：
10.1038/s41598-023-34546-5
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发表时间：
2023-05-05
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
急性酒精摄入产生主观中毒（SI）和反应（SR，如有价刺激和镇静），这对酒精相关风险具有重要意义。经历较少自伤的人可能更有可能在饮酒时从事危险行为。认知和情感过程背后的脑区域的灰质形态测量可能有助于告知主观中毒和反应的个体差异。酒精的主观效应在血液酒精浓度（BAC）曲线的不同分支之间存在差异（即BAC是上升还是下降；急性耐受性）。我们研究了灰质密度（GMD）与SI/SR之间的关系，作为BAC肢体的函数。健康的社交饮酒者（N = 89； 55名女性）完成了酒精挑战范式（目标BAC = 0.08 g/dL）和结构磁共振成像（MRI）。参与者完成了上升和下降BAC肢体的SR和SI测量。使用全脑、体素一般线性模型评估肢体GMD和SI/SR之间的关系。GMD估计是从显著聚类中提取的。采用层次回归评估四肢间GMD和SI/SR相关性的差异。在小脑中观察到上升肢的SI与GMD的显著关联。在降肢运动前皮质（BA6）和小脑中观察到SR与GMD之间的显著关联。我们确定了小脑和中央前回结构与中脑肢体间SI和SR之间的共同和独特的关联。功能成像研究可以进一步阐明与观察到的结构关联相关的主观酒精效应的独特维度。
Acute alcohol intake produces subjective intoxication (SI) and response (SR; e.g., valanced stimulation and sedation), which has important implications for alcohol-related risk. Individuals who experience less SI may be more likely to engage in risky behaviors while drinking. Gray matter morphometry in brain regions underlying cognitive and affective processes may help to inform individual differences in subjective intoxication and response. The subjective effects of alcohol vary between limbs of the blood alcohol concentration (BAC) curve (i.e., whether BAC is rising or falling; acute tolerance). We examined the relationship between gray matter density (GMD) and SI/SR as a function of BAC limb. Healthy social drinkers (N = 89; 55 women) completed an alcohol challenge paradigm (target BAC = 0.08 g/dL) and structural magnetic resonance imaging (MRI). Participants completed measures of SR and SI on ascending and descending BAC limbs. Association between GMD and SI/SR on each limb were assessed using whole-brain, voxel-wise general linear models. GMD estimates were extracted from significant clusters. Differences in association of GMD and SI/SR between limbs were assessed using hierarchical regression. Significant associations of SI with GMD on the ascending limb were observed in the cerebellum. A significant association between SR and GMD on the descending limb were observed in the pre-motor cortex (BA6) and cerebellum. We identified common and unique associations among cerebellum and pre-central gyrus structures with SI and SR between BAC limbs. Functional imaging studies may further clarify unique dimensions of subjective alcohol effects linked to the observed structural associations.
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影响因子：
4.2
作者：
Boissoneault, Jeff;Stennett, Bethany;Robinson, Michael E.
通讯作者：
Robinson, Michael E.
影响因子：
3.4
作者：
Amlung, Michael T.;Morris, David H.;McCarthy, Denis M.
通讯作者：
McCarthy, Denis M.
影响因子：
4.5
作者：
Boissoneault, Jeff;Penza, Charles W.;Bishop, Mark D.
通讯作者：
Bishop, Mark D.
共识文件：小脑功能的系统级观点：小脑、基底神经节和皮质之间的相互作用。
DOI：
10.1007/s12311-016-0763-3
发表时间：
2017-02
期刊：
Cerebellum (London, England)
影响因子：
--
作者：
Caligiore D;Pezzulo G;Baldassarre G;Bostan AC;Strick PL;Doya K;Helmich RC;Dirkx M;Houk J;Jörntell H;Lago-Rodriguez A;Galea JM;Miall RC;Popa T;Kishore A;Verschure PF;Zucca R;Herreros I
通讯作者：
Herreros I
DOI：
10.1002/hup.2565
发表时间：
2017-01
期刊：
Human psychopharmacology
影响因子：
--
作者：
Morris DH;Amlung MT;Tsai CL;McCarthy DM
通讯作者：
McCarthy DM