Childhood obesity and environmental chemicals.
Childhood obesity and environmental chemicals.
复制标题
DOI：
10.1002/msj.20229
复制
发表时间：
2011-01
影响因子：
--
通讯作者：
Birnbaum, Linda S.
中科院分区：
文献类型：
--
作者：
La Merrill, Michele;Birnbaum, Linda S.
在世界大部分地区，儿童和青少年肥胖和超重率持续上升。饮食结构、热量摄入过多、运动减少、遗传和建筑环境等危险因素是病因学研究的活跃领域。致肥胖假说认为，产前和围产期接触化学物质可能会增加儿童和青少年肥胖的风险，但这一假说的研究相对较少。这篇综述调查了许多类别的化学物质，并针对这些化学物质探索了这一假设。我们关注存在的人类数据，并讨论啮齿动物和细胞培养研究的结果。有机氯化学物质以及几类 PPAR 激动剂化学物质被确定为肥胖的可能危险因素。还对未来肥胖化学起源的流行病学和实验研究提出了建议。
Childhood and adolescent rates of obesity and overweight are continuing to increase in much of the world. Risk factors such as diet composition, excess caloric intake, decreased exercise, genetics, and the built environment are active areas of etiologic research. The obesogen hypothesis, which postulates that pre- and peri- natal chemical exposure can contribute to risk of childhood and adolescent obesity, remains relatively under-examined. This review surveys numerous classes of chemicals for which this hypothesis has been explored. We focus on human data where they exist and also discuss the findings of rodent and cell culture studies. Organochlorine chemicals as well as several classes of chemicals that are PPAR agonists are identified as possible risk factors for obesity. Recommendations for future epidemiologic and experimental research on the chemical origins of obesity are also given.
登录
查看更多内容
影响因子：
8
作者：
Biro FM;Galvez MP;Greenspan LC;Succop PA;Vangeepuram N;Pinney SM;Teitelbaum S;Windham GC;Kushi LH;Wolff MS
通讯作者：
Wolff MS
影响因子：
10.4
作者：
Alonso-Magdalena P;Vieira E;Soriano S;Menes L;Burks D;Quesada I;Nadal A
通讯作者：
Nadal A
影响因子：
10.4
作者：
Athanasiadou M;Cuadra SN;Marsh G;Bergman A;Jakobsson K
通讯作者：
Jakobsson K
影响因子：
10.4
作者：
Birnbaum LS;Fenton SE
通讯作者：
Fenton SE
影响因子：
120.7
作者：
Correll, Christoph U.;Manu, Peter;Olshanskiy, Vladimir;Napolitano, Barbara;Kane, John M.;Malhotra, Anil K.
通讯作者：
Malhotra, Anil K.