3D Bioprinted cancer models: Revolutionizing personalized cancer therapy.
3D Bioprinted cancer models: Revolutionizing personalized cancer therapy.
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DOI：
10.1016/j.tranon.2021.101015
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发表时间：
2021-04
影响因子：
5
通讯作者：
Hasan A
中科院分区：
文献类型：
--
作者：
Augustine R;Kalva SN;Ahmad R;Zahid AA;Hasan S;Nayeem A;McClements L;Hasan A
本文介绍了3D生物打印如何用于开发患者特定的癌症模型。含有患者来源的癌症和基质细胞的生物打印癌症模型有希望用于个性化癌症治疗，筛选3D生物打印构建体形成生理相关的细胞-细胞和细胞-基质相互作用。生物打印的癌症模型模拟了真实的肿瘤的3D异质性。在心血管疾病之后，癌症是世界范围内的主要死亡原因，对健康和经济造成毁灭性后果，特别是在发展中国家。抗癌药物反应的患者间差异进一步限制了治疗干预的成功。因此，个性化药物方法是这一患者群体的关键，涉及分子和遗传筛查以及患者对治疗方案的适当分层。然而，在许多癌症类型中，仍然缺乏与识别对特定抗癌剂有反应的患者的适当风险分层方法相关的知识。三维生物打印技术的最新进展已被广泛用于产生代表性的生物工程肿瘤体外模型，其重现了人类肿瘤组织和微环境，用于高通量药物筛选。生物打印过程涉及不同细胞类型的多层的精确沉积，结合能够基于计算机辅助设计生成3D生物工程组织的生物材料。生物打印的癌症模型含有患者来源的癌症和基质细胞以及遗传物质、细胞外基质蛋白和生长因子，代表了个性化癌症治疗筛选的有前途的方法。天然和合成生物聚合物都已用于支持个性化肿瘤模型/植入物内的细胞和生物材料的增殖。这些模型可以通过模拟真实的肿瘤的3D异质性来提供生理上相关的细胞-细胞和细胞-基质相互作用。在这里，我们回顾了3D生物打印肿瘤构建体作为个性化体外模型在抗癌药物筛选和建立精确治疗方案中的潜在应用。
This review describes how 3D bioprinting can be used for developing patient specific cancer models. Bioprinted cancer models containing patient-derived cancer and stromal cells is promising for personalized cancer therapy screening 3D bioprinted constructs form physiologically relevant cell–cell and cell–matrix interactions. Bioprinted cancer models mimic the 3D heterogeneity of real tumors. After cardiovascular disease, cancer is the leading cause of death worldwide with devastating health and economic consequences, particularly in developing countries. Inter-patient variations in anti-cancer drug responses further limit the success of therapeutic interventions. Therefore, personalized medicines approach is key for this patient group involving molecular and genetic screening and appropriate stratification of patients to treatment regimen that they will respond to. However, the knowledge related to adequate risk stratification methods identifying patients who will respond to specific anti-cancer agents is still lacking in many cancer types. Recent advancements in three-dimensional (3D) bioprinting technology, have been extensively used to generate representative bioengineered tumor in vitro models, which recapitulate the human tumor tissues and microenvironment for high-throughput drug screening. Bioprinting process involves the precise deposition of multiple layers of different cell types in combination with biomaterials capable of generating 3D bioengineered tissues based on a computer-aided design. Bioprinted cancer models containing patient-derived cancer and stromal cells together with genetic material, extracellular matrix proteins and growth factors, represent a promising approach for personalized cancer therapy screening. Both natural and synthetic biopolymers have been utilized to support the proliferation of cells and biological material within the personalized tumor models/implants. These models can provide a physiologically pertinent cell–cell and cell–matrix interactions by mimicking the 3D heterogeneity of real tumors. Here, we reviewed the potential applications of 3D bioprinted tumor constructs as personalized in vitro models in anticancer drug screening and in the establishment of precision treatment regimens.
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影响因子：
10
作者：
Abaci, Hasan E.;Guo, Zongyou;Coffman, Abigail;Gillette, Brian;Lee, Wen-han;Sia, Samuel K.;Christiano, Angela M.
通讯作者：
Christiano, Angela M.
影响因子：
5.7
作者：
Belgodere JA;King CT;Bursavich JB;Burow ME;Martin EC;Jung JP
通讯作者：
Jung JP
影响因子：
10
作者：
Cui, Haitao;Esworthy, Timothy;Zhang, Lijie Grace
通讯作者：
Zhang, Lijie Grace
影响因子：
5.7
作者：
Cibula, David;Poetter, Richard;Raspollini, Maria Rosaria
通讯作者：
Raspollini, Maria Rosaria
影响因子：
5.7
作者：
Campbell, Aleli;Mohl, Jonathon E.;Boland, Thomas
通讯作者：
Boland, Thomas