Mating increases Drosophila melanogaster females' choosiness by reducing olfactory sensitivity to a male pheromone.
Mating increases Drosophila melanogaster females' choosiness by reducing olfactory sensitivity to a male pheromone.
复制标题
DOI：
10.1038/s41559-021-01482-4
复制
发表时间：
2021-08
影响因子：
16.8
通讯作者：
Billeter, Jean-Christophe
中科院分区：
文献类型：
--
作者：
Kohlmeier, Philip;Zhang, Ye;Gorter, Jenke A.;Su, Chih-Ying;Billeter, Jean-Christophe
在选择配偶时具有高度选择性的雌性可能会面临未交配或延迟开始繁殖的风险。因此，在雄性稀少的情况下，减少雌性的选择性是有益的，但如果雄性变得更加频繁，就会产生适应不良。女性该如何解决这个问题呢？一妻多夫制已被提议作为该问题的解决方案。雌性多次交配会导致交配状态依赖的选择性，处女在选择第一个交配对象时几乎没有选择性，此后变得更加挑剔。这种选择性的可塑性将确保及时获得精子，并使雌性在以后的交配过程中提高后代的质量。然而，这种机制仍然没有记录。在这里，我们发现雌性黑腹果蝇在第一次交配后变得更加选择性，从而表现出交配状态依赖性的选择性，并确定了调节这种可塑性的神经激素机制。交配会触发保幼激素的释放增加，从而使 OR47b 嗅觉神经元对雄性产生的催情信息素不敏感。这导致人们更加偏爱富含信息素的雄性。除了为长期进化预测提供机械基础外，这些数据表明，黑腹果蝇的间性选择，可能还有所有一妻多夫、储存精子的物种，都受到交配雌性的强烈影响，因为处女雌性是非选择性的。保幼激素通过改变昆虫的提示反应来影响（社会）行为，但分子机制仍不清楚。黑腹果蝇 OR47b 嗅觉神经元的神经激素调节提供了保幼激素如何调节社会可塑性的明确场景。
Females that are highly selective when choosing a mate run the risk of remaining unmated or delaying commencing reproduction. A reduction in female choosiness would therefore become beneficial in conditions where males are rare, but it would be maladaptive if males become more frequent; how can female resolve this issue? Polyandry has been proposed as a solution to this problem. Multiple mating by females would allow mating status-dependent choosiness, with virgins selecting their first mating partner with little selectivity and becoming choosier thereafter. This plasticity in choosiness would ensure a timely acquisition of sperm and enable females to increase offspring quality during later mating. However, such a mechanism remains undocumented. Here, we show that Drosophila melanogaster females display mating status-dependent choosiness by becoming more selective after their first mating, and identify the neurohormonal mechanisms that regulate this plasticity. Mating triggers the increased release of juvenile hormone, which desensitizes the OR47b olfactory neurons to an aphrodisiac pheromone produced by males. This results in an elevated preference for pheromone-rich males. Besides providing a mechanistic basis to a long-standing evolutionary prediction, these data suggest that intersexual selection in D. melanogaster, and possibly in all polyandrous, sperm-storing species, is strongly influenced by mated females as virgin females are non-selective. Juvenile hormone influences (social) behaviour by changing cue responsiveness across insects but the molecular mechanisms remained unclear. The neurohormonal modulation of OR47b olfactory neurons in D. melanogaster provides an explicit scenario of how juvenile hormone modulates social plasticity.
登录
查看更多内容
影响因子：
9.8
作者：
Benton, Richard;Sachse, Silke;Michnick, Stephen W;Vosshall, Leslie B
通讯作者：
Vosshall, Leslie B
影响因子：
9.8
作者：
Hussain A;Üçpunar HK;Zhang M;Loschek LF;Grunwald Kadow IC
通讯作者：
Grunwald Kadow IC
影响因子：
64.8
作者：
Billeter, Jean-Christophe;Atallah, Jade;Levine, Joel D.
通讯作者：
Levine, Joel D.
影响因子：
5.4
作者：
Chertemps T;François A;Durand N;Rosell G;Dekker T;Lucas P;Maïbèche-Coisne M
通讯作者：
Maïbèche-Coisne M
影响因子：
2.5
作者：
Bateman, PW;Gilson, LN;Ferguson, JWH
通讯作者：
Ferguson, JWH