Influences of strontium on the phase composition and lattice structure of biphasic calcium phosphate
Influences of strontium on the phase composition and lattice structure of biphasic calcium phosphate
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锶对双相磷酸钙物相组成和晶格结构的影响
DOI：
10.1016/j.ceramint.2021.01.295
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发表时间：
2021-02
影响因子：
5.2
通讯作者：
William Weijia Lu
中科院分区：
文献类型：
--
作者：
Mengjing Wang;Xiang Ge;Zhenduo Cui;Shuilin Wu;Shengli Zhu;Yanqin Liang;Zhaoyang Li;William Weijia Lu
羟基磷灰石（HAp）和β-磷酸三钙（β-TCP）因其具有优异的生物相容性而广泛应用于骨移植材料。然而，HAp和β-TCP的降解速率与成骨速率不匹配，这限制了它们的临床应用。因此，形成双相磷酸钙（BCP）是控制材料生物降解速率的一种有前途的方法。此外，锶（Sr）是促进成骨、抑制骨吸收的重要元素。因此，本研究重点研究了 Sr 对通过化学沉淀和高温煅烧方法合成的不同 Sr 浓度（1、5 和 15 mol%）的 BCP 的影响。在本研究中，我们假设在 Rietveld 精修过程中将 Sr 掺杂到 β-TCP 的 Ca(5) 和 HAp 的 Ca(1) 和 Ca(2) 中。根据X射线衍射（XRD）图谱获得的Rietveld精修结果，随着Sr浓度的增加，HAp的质量百分比首先下降，这是由于HAp结构的畸变，导致HAp稳定性下降以及从HAp到β-TCP的相变。然而，当 Sr 的浓度达到 15 mol% 时，HAp 的质量百分比增加，这可能是由于 Ca 的扩散从 β-TCP 到缺钙磷灰石的相变。此外，晶格常数和体积的增加表明 Sr 已成功掺杂到 β-TCP 和 HAp 的晶格中，因为 Sr2+ 的离子半径（0.113 nm）大于 Ca2+ 的离子半径（0.099 nm）。 X射线光电子能谱（XPS）结果显示，Sr3d和Sr3p的强度随着Sr浓度的增加而增加，这表明Sr不仅存在于样品的表面，而且存在于β-TCP和HAp的晶体结构中。
Hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) are widely used in bone graft materials, because they have excellent biocompatibility. However, the degradation rates of HAp and β-TCP do not match the rate of osteogenesis, which limits their clinical applications. Therefore, forming biphasic calcium phosphate (BCP) is a promising method to control the biodegradation rate of the material. In addition, strontium (Sr) is an important element that promotes osteogenesis and inhibits bone absorption. Therefore, this study focused on the effects of Sr in the as-synthesized BCP with varied Sr concentrations of 1, 5, and 15 mol%, which are synthesized by chemical precipitation and a high-temperature calcination method. In this study, we assume that Sr is doped into Ca(5) of β-TCP and Ca(1) & Ca(2) of HAp during the Rietveld refinement. On the basis of the Rietveld refinement results obtained from X-ray diffraction (XRD) patterns, with increasing Sr concentration, the mass percentage of HAp decreases first, which is due to the distortion of the HAp structure, resulting in a decrease in HAp stability and phase variation from HAp to β-TCP. However, when the concentration of Sr reaches 15 mol%, the mass percentage of HAp increases, which may be because of the phase transformation from β-TCP to calcium-deficient apatite by the diffusion of Ca. In addition, the increase in the lattice constants and volumes indicates that Sr has been successfully doped into the crystal lattices of both β-TCP and HAp, since the ion radius of Sr2+(0.113 nm) is larger than the ion radius of Ca2+(0.099 nm). As shown in the X-ray photoelectron spectroscopy (XPS) results, the intensities of Sr3d and Sr3p increase with increasing Sr concentrations, which indicates that Sr is not only on the surface of the sample but also in the crystalline structures of both β-TCP and HAp.
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影响因子：
2.8
作者：
Kazuhiko Kawabata;Tomoyuki Yamamoto;A. Kitada
通讯作者：
Kazuhiko Kawabata;Tomoyuki Yamamoto;A. Kitada
影响因子：
2.1
作者：
Jimi E;Hirata S;Osawa K;Terashita M;Kitamura C;Fukushima H
通讯作者：
Fukushima H
影响因子：
5.2
作者：
I. Ullah;M. A. Siddiqui;S. Kolawole;H. Liu;Ji Zhang;L. Ren;Ke Yang
通讯作者：
I. Ullah;M. A. Siddiqui;S. Kolawole;H. Liu;Ji Zhang;L. Ren;Ke Yang
影响因子：
5.2
作者：
Nabor Oswvaldo Martínez-Gracida;S. C. Esparza-González;N. A. Castillo-Martínez;A. Serrano-Medina;Imelda Olivas-Armendáriz;L. G. Campos-Múzquiz;E. Múzquiz-Ramos
通讯作者：
Nabor Oswvaldo Martínez-Gracida;S. C. Esparza-González;N. A. Castillo-Martínez;A. Serrano-Medina;Imelda Olivas-Armendáriz;L. G. Campos-Múzquiz;E. Múzquiz-Ramos
影响因子：
1.9
作者：
O. Kaygili
通讯作者：
O. Kaygili