Investigating neuropsychological and reward-related deficits in a chronic corticosterone-induced model of depression.
Investigating neuropsychological and reward-related deficits in a chronic corticosterone-induced model of depression.
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在慢性皮质酮引起的抑郁模型中研究神经心理学和奖励相关的缺陷。
DOI：
10.1016/j.psyneuen.2022.105953
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发表时间：
2023-01
影响因子：
3.7
通讯作者：
Robinson, Emma S. J.
中科院分区：
文献类型：
--
作者：
Hales, Claire A.;Stuart, Sarah A.;Griffiths, Jennifer;Bartlett, Julia;Arban, Roberto;Hengerer, Bastian;Robinson, Emma S. J.
慢性应激是导致抑郁症（MDD）发生的一个已知危险因素，常用于在啮齿类动物中诱导抑郁样表型。在啮齿类动物中也观察到类似的表型效应，当长期使用应激激素皮质酮时。在这项研究中，我们调查了慢性皮质酮治疗的神经心理学后果，在雄性大鼠使用两个翻译啮齿动物实验的情感偏见，判断偏见任务（JBT）和情感偏见测试（ABT）。我们还使用奖励学习试验（RLA）和蔗糖偏好试验（SPT）来量化奖励相关行为。在慢性皮质酮治疗组中观察到决策的负偏差，但仅在每次行为会话前不久给予治疗时。同样剂量的皮质酮，当每天给予完成后的行为会话没有影响。慢性皮质酮治疗并没有增强ABT诱导的急性药理学或应激操作的负性情感偏见，但奖励学习和奖励敏感性钝化。对接受慢性皮质酮的动物的脑组织进行分析，发现海马神经发生减少，这与先前的研究一致，表明皮质酮诱导的神经营养缺陷。综上所述，这些数据表明，慢性皮质酮治疗诱导神经心理学效应与奖励学习，记忆和决策中的负偏差的变化有关，但这些决策偏差取决于奖励结果是否在药物的急性效应期间经历。这些研究结果表明，心理和生物因素之间的一个重要的相互作用，导致在这个模型中的决策负偏差。慢性皮质酮（CORT）治疗引起的负面决策偏见。消极的决策偏差取决于治疗时机。慢性CORT治疗导致奖励学习和奖励敏感性受损。CORT治疗没有增强药理学或应激诱导的负偏倚。慢性CORT治疗减少海马神经发生。
Chronic stress is a known risk factor for the development of major depression (MDD) and is commonly used to induce a depression-like phenotype in rodents. Similar phenotypic effects are also observed in rodents when treated chronically with the stress hormone corticosterone. In this study, we investigated the neuropsychological consequences of chronic corticosterone treatment in male rats using two translational rodent assays of affective bias, the judgement bias task (JBT) and affective bias test (ABT). We also used the reward learning assay (RLA) and sucrose preference test (SPT) to quantify reward-related behaviours. Negative biases in decision-making were observed in the chronic corticosterone-treated group but only when the treatment was given shortly before each behavioural session. The same dose of corticosterone, when given daily after completion of the behavioural session had no effects. Chronic corticosterone treatment did not potentiate negative affective biases in the ABT induced by either an acute pharmacological or stress manipulation but both reward learning and reward sensitivity were blunted. Analysis of the brain tissue from animals receiving chronic corticosterone found reduced hippocampal neurogenesis consistent with previous studies suggesting corticosterone-induced neurotrophic deficits. Taken together, these data suggest chronic corticosterone treatment induces neuropsychological effects related to changes in reward learning, memory and negative biases in decision making, but these decision-making biases depend on whether rewarding outcomes were experienced during the acute effects of the drug. These findings suggest an important interaction between psychological and biological factors resulting in negative biases in decision-making in this model. Chronic corticosterone (CORT) treatment induced negative decision-making biases. Negative decision-making biases were dependent on treatment timing. Chronic CORT treatment caused impairments in reward learning and reward sensitivity. CORT treatment did not potentiate pharmacological or stress induced negative bias. Chronic CORT treatment reduced neurogenesis in the hippocampus.
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DOI：
10.1016/j.euroneuro.2017.09.008
发表时间：
2017-12
期刊：
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
影响因子：
--
作者：
Hales CA;Houghton CJ;Robinson ESJ
通讯作者：
Robinson ESJ
影响因子：
17.7
作者：
Harmer, Catherine J.;O'Sullivan, Ursula;Cowen, Philip J.
通讯作者：
Cowen, Philip J.
影响因子：
7.6
作者：
Enkel, Thomas;Gholizadeh, Donya;Vollmayr, Barbara
通讯作者：
Vollmayr, Barbara
影响因子：
10.6
作者：
Bruce, ML
通讯作者：
Bruce, ML
影响因子：
7.3
作者：
Hales CA;Stuart SA;Anderson MH;Robinson ES
通讯作者：
Robinson ES