Vascular endothelial growth factor: much more than an angiogenesis factor.
Vascular endothelial growth factor: much more than an angiogenesis factor.
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DOI：
10.1091/mbc.e09-07-0591
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发表时间：
2010-02-01
影响因子：
3.3
通讯作者：
Senger DR
中科院分区：
文献类型：
--
作者：
Senger DR
血管内皮生长因子（VEGF）是胚胎血管发生和与包括癌症在内的各种病理学相关的血管生成所必需的细胞因子。然而，VEGF还具有其他不太广泛认识的功能。早期的研究揭示了VEGF转录物在没有进行中的新血管形成的成人组织中的广泛表达，从而预测了与血管生成不同的其他VEGF功能。最近的研究证实，VEGF确实具有多种额外的功能，包括正常维持内皮细胞和神经细胞区室。这些发现对于在以抑制病理性血管生成为治疗目标的患者中使用VEGF拮抗剂和VEGF受体拮抗剂具有重要意义。
Vascular endothelial growth factor (VEGF) is best known as a cytokine essential for embryonic vasculogenesis and for the angiogenesis associated with various pathologies including cancer. However, VEGF also serves other functions that are less widely recognized. An early study revealed widespread expression of VEGF transcripts in adult tissues devoid of ongoing neovascularization, thereby predicting additional VEGF functions distinct from angiogenesis. More recent studies have confirmed that VEGF does indeed serve multiple additional functions, including normal maintenance of endothelial and neural cell compartments. These findings have important implications for the use of VEGF antagonists and VEGF receptor antagonists in patients for which inhibition of pathological angiogenesis is the therapeutic goal.
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影响因子：
3.7
作者：
Saint-Geniez M;Maharaj AS;Walshe TE;Tucker BA;Sekiyama E;Kurihara T;Darland DC;Young MJ;D'Amore PA
通讯作者：
D'Amore PA
影响因子：
158.5
作者：
Eremina, Vera;Jefferson, J. Ashley;Quaggin, Susan E.
通讯作者：
Quaggin, Susan E.
影响因子：
3.3
作者：
BERSE, B;BROWN, LF;SENGER, DR
通讯作者：
SENGER, DR
影响因子：
56.9
作者：
KECK, PJ;HAUSER, SD;CONNOLLY, DT
通讯作者：
CONNOLLY, DT
影响因子：
56.9
作者：
SENGER, DR;GALLI, SJ;DVORAK, HF
通讯作者：
DVORAK, HF